Zika Virus-Associated Guillain-Barré Syndrome in a Returning US Traveler

Details

• Personal Author:
  Beattie J ; Caplan A ; Crowley G ; Dufort E ; Kwon S ; Lee G ; Manko JA ; Murthy V ; Nolan A ; Parajuli S ; Pastula DM ; Pleninger P ; Sanger M
• Description:
  Zika virus (ZIKV) infection has been associated with Guillain-Barré syndrome (GBS). Roughly 60% of people in countries such as the United States live in areas at risk of seasonal spread of ZIKV. Zika virus belongs to a class of diseases that is not typically seen in hospital settings across the United States and Europe. We describe the case presentation, management, and treatment of ZIKV infection complicated by GBS. A 64-year-old woman with recent travel to the Dominican Republic presented with rash followed by an acute, ascending polyneuropathy consistent with GBS. She was confirmed to have an acute ZIKV infection by detection of ZIKV nucleic acid by reverse transcription-polymerase chain reaction. She met Brighton Collaboration criteria level 1 evidence for GBS. She received 2 courses of intravenous immunoglobulin and slowly improved, but still had weakness at discharge. More research is needed to identify the pathophysiology behind ZIKV-associated GBS and its optimal treatment. Prevention is fundamental to limiting infection and spread of ZIKV. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Occupational Health Safety Viral Diseases
• Keywords:
  Disease Prevention Infection Prevention Infectious Diseases Neurological Diseases Neuropathy Pathogens Viral Diseases
• ISSN:
  1056-9103
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; New York ; OSHA Region 2 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  6
• NIOSHTIC Number:
  nn:20055497
• Citation:
  Infect Dis Clin Pract 2018 Nov; 26(6):e80-e84
• Contact Point Address:
  Anna Nolan, MD, MS, Division of Pulmonary, Critical Care and Sleep, New York University School of Medicine, New Bellevue, 7N Room 24, 462 1st Ave, New York, NY 10016
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Infectious Diseases in Clinical Practice
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c3ff4c8b1cb74d876ea574c923075f329fc7ca9c9a4f326b050a56b71185ebf93940e16db00e45c868a4370856775c9887940c204e1ec64fb1f2d822345fca1
• Download URL:
  https://stacks.cdc.gov/view/cdc/213334/cdc_213334_DS1.pdf
• File Type:
  [PDF - 133.24 KB ]