Quantitation of secretory IgA in chronic pulmonary disease with particular reference to coal workers pneumoconiosis.

Details

• Personal Author:
  Burrell R ; Lapp, N. Leroy ; Lewis, Daniel M.
• Description:
  The occurrence of secretory immunoglobulin-A (IgA) in chronic pulmonary disease was studied in humans. Saliva and serum samples were collected from healthy normal individuals, from coal miners (SIC-1211) with simple or complicated pneumoconiosis, and from hospital patients with chronic lung diseases not associated with coal mining. The quantity of IgA in saliva was determined by electroimmunodiffusion, and the concentrations in whole serum samples were determined by a modification of the radial diffusion method. Some samples also were tested for influenza PR-8 hemagglutinin inhibition antibodies. High serum IgA concentrations correlated with high salivary concentrations in subjects with chronic pulmonary disease. Serum IgA concentrations were elevated in coal miners with simple and complicated pneumoconiosis, but salivary IgA concentrations were elevated only in miners with simple pneumoconiosis. Cigarette smoking suppressed secretory IgA production in older normal subjects but not in those with pneumoconiosis or other chronic respiratory disorders. About 40 percent of the saliva samples tested contained antiinfluenza PR-8 antibodies. The authors suggest that the salivary globulins in these subjects represent functional antibodies. [Description provided by NIOSH]
• Subjects:
  Diagnosis Hematologic Tests Lung Diseases Mining Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Diagnostic-techniques Diagnostic-tests Hematology Lung-disorders Mine-workers Occupational-medicine Pulmonary-system-disorders
• Publisher:
  Unwin Brothers Limited
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALFORD - Appalachian Laboratory for Occupational Respiratory Disease
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• NIOSHTIC Number:
  nn:00117328
• Citation:
  Inhaled Particles III: Proceedings of an International Symposium Organized by the British Occupational Hygiene Society in London, September 14-23, 1970. Walton WH, ed. Old Woking, England: Unwin Brothers Limited, 1971 Jan; 2:579-587
• Contact Point Address:
  Appalachian Laboratory for Occupational Respiratory Diseases, Department of Health, Education and Welfare, U.S. Public Health Service, Bureau of Occupational Safety and Health, Environmental Health Service, Morgantown, West Virginia 26506, U.S.A.
• Editor(s):
  Walton WH
• Federal Fiscal Year:
  1971
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  1211 - Bituminous Coal and Lignite - (SIC)
• Source Full Name:
  Inhaled Particles III: Proceedings of an International Symposium Organized by the British Occupational Hygiene Society in London, September 14-23, 1970
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:229ae9f8e9f71d08fd1b29cc8acf104c3754677f5a2d20e5bf43641a1b4153d831f90f7fb1ec0692514426f3c27700100bb89bd21690ce0eea2b0b2f080580e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/184459/cdc_184459_DS1.pdf
• File Type:
  [PDF - 3.92 MB ]