Immunoglobulin levels in berylliosis.

Details

• Personal Author:
  Morgan WKC ; Resnick H ; Morgan WKC ; Resnick H
• Description:
  The effects of beryllium (7440417) on serum protein and immunoglobulin concentrations were studied. Serum samples were collected from a group of beryllium workers and analyzed for the presence of immunoglobulin-G (IgG), immunoglobulin-E (IgE). Workers included those with confirmed chronic berylliosis, those with resolved acute berylliosis and no residual symptoms, those with beryllium dermatitis, and those employed at the beryllium facilities for at least 15 years with no symptoms of berylliosis. All groups had marked hypergammaglobulinemia with significantly elevated IgG concentrations, including over 80 percent of the exposed workers with no clinical symptoms of beryllium toxicity. Changes in IgA and IgM occurred at random. The agar double diffusion and radial immunodiffusion methods used to evaluate IgD and IgE concentrations were not sensitive enough to detect low concentrations of these immunoglobulins. IgE could not be detected in the test subjects. When IgD was detected, its presence did not correlate with any other factors. The authors conclude that an elevated IgG concentration can be used along with other evidence in the diagnosis of berylliosis. [Description provided by NIOSH]
• Subjects:
  Diagnosis Hematologic Diseases Hematologic Tests Metals Occupational Health Safety
• Keywords:
  Blood-disorders Diagnostic-techniques Diagnostic-tests Hematology Light-metals Occupational-medicine
• Publisher:
  Unwin Brothers Limited
• Document Type:
  Text
• Genre:
  Proceedings ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALFORD - Appalachian Laboratory for Occupational Respiratory Disease ; ALFORD - Appalachian Laboratory for Occupational Respiratory Disease
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  2
• NIOSHTIC Number:
  nn:00117327
• Citation:
  Inhaled Particles III: Proceedings of an International Symposium Organized by the British Occupational Hygiene Society in London, September 14-23, 1970. Walton WH, ed. Old Woking, England: Unwin Brothers Limited, 1971 Jan; 2:589-598
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7) ; Beryllium (CAS RN 7440-41-7)
• Editor(s):
  Walton WH ; Walton WH
• Federal Fiscal Year:
  1971
• Peer Reviewed:
  False
• Source Full Name:
  Inhaled Particles III: Proceedings of an International Symposium Organized by the British Occupational Hygiene Society in London, September 14-23, 1970
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:78242e67ced5fd7383d99819418af81c389c2b90ff00232aea3be1f0a7ab0fb6285392f84cdca0873ced7957eec7c82b5053beb5acb43848eda752496fe94a9a
• Download URL:
  https://stacks.cdc.gov/view/cdc/184458/cdc_184458_DS1.pdf
• File Type:
  [PDF - 3.80 MB ]