A purified extract from cotton bracts induces airway constriction in humans.

Details

• Personal Author:
  Bouhuys A ; Buck MG
• Description:
  Airway constriction responses were studied in subjects exposed to cotton bract extracts. Nonoccupationally exposed volunteers inhaled various types of bract extract for 10 minutes. Respiratory function was evaluated every 30 minutes for 2.5 to 3 hours after exposure. The mean decrease in maximum expiratory flow was 40 percent and forced expiratory volume in 1 second was 20 and 5 percent, respectively, for standard crude bract extract. Maximal responses occurred 90 to 120 minutes after exposure onset. Cigarette smokers were less responsive than nonsmokers. Most subjects did not react to extracts from a glandless type of cotton. The agents responsible for producing the constrictor response were soluble in water and were resistant to heat and pH changes. The agents had low molecular weights and neutral charges, and possibly contained amino-nitrogen and hexose residues. The authors suggest that the potency of cotton mill dust on respiratory reactivity in humans may be due to the water solubility of the dust. The harmful effects of the dust could be reduced by washing the cotton before it is processed. [Description provided by NIOSH]
• Subjects:
  Chemistry Dust Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Smokers Tobacco Products
• Keywords:
  Chemical Properties Cigarette Smoking Cotton Dust Dust Inhalation Lung Function Physical Properties Pulmonary System Disorders
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  79
• Issue:
  4
• NIOSHTIC Number:
  nn:00115328
• Citation:
  Chest 1981 Apr; 79(4)(Suppl):43S-49S
• Contact Point Address:
  Dr. Buck, PO Box 3333, Pulmonary Section, Yale University, New Haven 06510
• Federal Fiscal Year:
  1981
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  True
• Start Date:
  19770701
• Source Full Name:
  Chest
• Supplement:
  Supplement
• End Date:
  19790131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:49f589d390c88892e1c6de4a17ae61343543988ded1f396bd268e985b854c92581550f1030982881e929d2bc58d5f11a2acff5cc70db5d57aa2e2f9ed8eaf1b0
• Download URL:
  https://stacks.cdc.gov/view/cdc/184432/cdc_184432_DS1.pdf
• File Type:
  [PDF - 1.49 MB ]