Effects of heavy metal ions on selected oxidative metabolic processes in rat alveolar macrophages.

Details

• Personal Author:
  Bowman L ; Castranova, Vincent ; Miles PR ; Reasoner MJ
• Description:
  The effects of four heavy metal cations, cadmium 2+ (22537480), mercury 2+ (14302875), nickel 2+ (14701225), and lead 2+ (14280503), on some of the oxidative metabolic events in rat alveolar macrophages were studied. The metals used in the experiments were added to macrophage suspensions as either chloride or acetate salts. Oxygen consumption, glucose metabolism, and the release of active oxygen species were measured in macrophage suspensions at rest and during phagocytosis. All four heavy metals depressed the oxygen consumption and glucose metabolism which occurred in alveolar macrophages at rest by about 60 to 95 percent. During phagocytosis there was release of reactive forms of oxygen from the cells, a two to threefold increase in oxygen consumption, but no change in glucose metabolism from that which occurred in resting cells. Release of active oxygen from the cells and oxygen consumption during phagocytosis were inhibited 75-85% by the metals. The authors conclude that heavy metals inhibit oxidative metabolic processes in alveolar macrophages and, thus, may diminish the antibacterial activity of these cells. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Chemistry Energy Metabolism Laboratories Metals, Heavy Occupational Health Oxidants Poisoning Safety
• Keywords:
  Air-contaminants Antibacterial-agents Cellular-reactions Chemical-reactions Heavy-metals Laboratory-animals Metabolic-effects Metallic-poisons Metallic-salts NIOSH-Author Oxidative-metabolism

  More +
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  14-23
• Volume:
  53
• Issue:
  1
• NIOSHTIC Number:
  nn:00095108
• Citation:
  Toxicol Appl Pharmacol 1980 Mar; 53(1):14-23
• CAS Registry Number:
  Cd2+ (CAS RN 22537-48-0) ; Lead(2+) (CAS RN 14280-50-3) ; Mercury(2+) (CAS RN 14302-87-5) ; Ni2+ (CAS RN 14701-22-5)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e20267abdcfe7ae62066f4fcf6d0563a44f56244a9dd382d9001afde0a5474ad5cef8eed3a20e2c74edbb9787b15a8731ba140bfbf0a7611b20d5bf97dae9169
• Download URL:
  https://stacks.cdc.gov/view/cdc/184347/cdc_184347_DS1.pdf
• File Type:
  [PDF - 785.40 KB ]