Absence of airway hyperreactivity to methacholine in a worker sensitized to toluene diisocyanate (TDI).

Details

• Personal Author:
  Bernstein IL ; Blanchard J ; Brooks, Stuart M. ; Gallagher J ; Smith AB
• Description:
  A case report of occupational asthma due to toluene diisocyanate (26471625) (TDI) is described. A 43 year old nonsmoking female complained of throat irritation and a nonproductive cough after working in a polyester resin manufacturing factory for 2.5 years. Detailed immunologic studies including those for p-tolyl isocyanate IgE antibodies and the presence of a leukocyte inhibition factor for isocyanate antigen were negative. Methacholine challenges also were negative. A dose related response to TDI was observed on bronchial provocation testing using TDI concentrations of 0.0165 and 0.030 parts per million. The authors conclude that airway response to TDI may not always be accompanied by hyperactivity to methacholine, and that screening procedures utilizing methacholine challenges may not always identify sensitized workers. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Case Reports Irritants Manufacturing And Industrial Facilities Occupational Health Plastics Respiratory Tract Diseases Safety
• Keywords:
  Bronchial-asthma Case-studies Chemical-factory-worker Clinical-symptoms JOCMA7 NIOSH-Author Plastic-products Respiratory-irritants Respiratory-system-disorders Serological-analysis
• ISSN:
  0096-1736
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  327-331
• Volume:
  22
• Issue:
  5
• NIOSHTIC Number:
  nn:00095062
• Citation:
  J Occup Med 1980 May; 22(5):327-331
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:433454542b1ceb900a8710e89a33e721b33de93d72d7685d51e7b6324a0cba4d180b76516a5527991026510a7158d5a18070fac302caf5495521dfa589217e01
• Download URL:
  https://stacks.cdc.gov/view/cdc/184346/cdc_184346_DS1.pdf
• File Type:
  [PDF - 477.58 KB ]