House Dust Endotoxin and Wheeze in the First Year of Life

Details

• Personal Author:
  Burge HA ; Gold DR ; Milton DK ; Park, Ju-Hyeong ; Spiegelman DL
• Description:
  We examined endotoxin exposure and wheezing episodes during the first year of life in a birth cohort of 499 infants with one or both parents having a history of asthma or allergy. We measured endotoxin in settled dust from the baby's bed, bedroom floor, family room, and kitchen floor within the first 3 mo after birth. The primary outcomes were any wheeze (versus no wheeze), and repeated wheeze (versus one or no report of wheeze). We found a significant univariate association of elevated endotoxin (> or = 100 EU/ mg) in family room dust with increased risk of any wheeze (Relative Risk = 1.29, 95% CI = 1.03-1.62). The association was not confounded by cockroach allergen, lower respiratory illness (croup, bronchitis, bronchiolitis, and pneumonia), smoking during pregnancy, lower birth weight, maternal asthma, presence of dog, and race/ethnicity in a multivariate model; the multivariate relative risk (RR = 1.33) was marginally significant (95% CI: 1.00-1.76, p < 0.05). In a multivariate model, controlling for the above covariates, elevated endotoxin in family room dust was significantly associated with increased risk (RR = 1.56, 95% CI = 1.03-2.38) of repeated wheeze. These results suggest that home endotoxin exposure may independently increase risk of any wheeze and repeated wheeze during the first year of life for children with a familial predisposition to asthma or allergy. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Endotoxins Epidemiology Hypersensitivity Irritants Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Allergies Bronchial-asthma Children Pulmonary-system-disorders Respiratory-irritants Respiratory-system-disorders Statistical-analysis
• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  322-328
• Volume:
  163
• Issue:
  2
• NIOSHTIC Number:
  nn:20021832
• Citation:
  Am J Respir Crit Care Med 2001 Feb; 163(2):322-328
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:694b4750de558b848ffd36e0b44f87d3b71d359fd182b0edf70a89c824cb6795ee40d4925d0807d226184cf1670b66f59652eca6e2a1f62c162a40bc75ede194
• Download URL:
  https://stacks.cdc.gov/view/cdc/198929/cdc_198929_DS1.pdf
• File Type:
  [PDF - 145.88 KB ]