Epidemiology of Mycobacterium bovis Disease in Humans, the Netherlands, 1993–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Majoor, Christof J. ; Magis-Escurra, Cecile ; van Ingen, Jakko ; Boeree, Martin J. ; van Soolingen, Dick
• Description:
  In the Netherlands, 1.4% of tuberculosis (TB) cases are caused by Mycobacterium bovis. After we admitted 3 patients with M. bovis infections to our reference hospital, we conducted a retrospective analysis of all M. bovis disease in the Netherlands during 1993-2007. We analyzed data from 231 patients for clinical, demographic, treatment, and outcome characteristics and for risk factors. Most patients were native Dutch (n = 138; 59.7%) or Moroccan (n = 54; 23.4%). Disease was mainly extrapulmonary (n = 136; 58.9%). Although 95 patients had pulmonary disease, person-to-person transmission did not occur, as shown by structural DNA fingerprinting analysis. Lymph node TB was more likely to develop in women (p<0.0001), whereas pulmonary M. bovis disease developed more frequently in men (p<0.0001). Diagnosis was accurate but delayed and led to inadequate treatment in 26% of the cases. Proportion of deaths from M. bovis disease was higher than that for M. tuberculosis disease.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Anti-TNF-α Antitubercular Agents Child Child, Preschool DNA Fingerprinting Emigrants And Immigrants Epidemiology Extrapulmonary Disease Female Gender Differences Humans Infant Infant, Newborn M. Bovis M. Tuberculosis Disease Male Middle Aged Mycobacterium Bovis Netherlands Research Risk Factors Treatment Outcome Tuberculosis Tuberculosis, Lymph Node Tuberculosis, Pulmonary Tuberculosis And Other Mycobacteria

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• Source:
  Emerg Infect Dis. 17(3):457-463.
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:789fea4d159afe2d6db8a8e45c16a8f4aaff8ae968c9d63dcc30299f8ae8c39e
• Download URL:
  https://stacks.cdc.gov/view/cdc/18433/cdc_18433_DS1.pdf
• File Type:
  [PDF - 289.24 KB ]