Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Majoor, Christof J. ; Magis-Escurra, Cecile ; van Ingen, Jakko ; Boeree, Martin J. ; van Soolingen, Dick
Majoor, Christof J. ; Magis-Escurra, Cecile ; van Ingen, Jakko ; Boeree, Martin J. ; van Soolingen, Dick Less -
Description:
In the Netherlands, 1.4% of tuberculosis (TB) cases are caused by Mycobacterium bovis. After we admitted 3 patients with M. bovis infections to our reference hospital, we conducted a retrospective analysis of all M. bovis disease in the Netherlands during 1993-2007. We analyzed data from 231 patients for clinical, demographic, treatment, and outcome characteristics and for risk factors. Most patients were native Dutch (n = 138; 59.7%) or Moroccan (n = 54; 23.4%). Disease was mainly extrapulmonary (n = 136; 58.9%). Although 95 patients had pulmonary disease, person-to-person transmission did not occur, as shown by structural DNA fingerprinting analysis. Lymph node TB was more likely to develop in women (p<0.0001), whereas pulmonary M. bovis disease developed more frequently in men (p<0.0001). Diagnosis was accurate but delayed and led to inadequate treatment in 26% of the cases. Proportion of deaths from M. bovis disease was higher than that for M. tuberculosis disease.
Subject:
[+]
Adolescent
Adult
Aged
Aged, 80 And Over
Anti-TNF-α
Antitubercular Agents
Child
Child, Preschool
DNA Fingerprinting
Emigrants And Immigrants
Epidemiology
Extrapulmonary Disease
Female
Gender Differences
Humans
Infant
Infant, Newborn
M. Bovis
M. Tuberculosis Disease
Male
Middle Aged
Mycobacterium Bovis
Netherlands
Research
Risk Factors
Treatment Outcome
Tuberculosis
Tuberculosis, Lymph Node
Tuberculosis, Pulmonary
Tuberculosis And Other Mycobacteria

Source:
Emerg Infect Dis. 17(3):457-463.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:789fea4d159afe2d6db8a8e45c16a8f4aaff8ae968c9d63dcc30299f8ae8c39e
File Type:

Supporting Files

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