Epidemiology of Mycobacterium bovis Disease in Humans, the Netherlands, 1993–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Majoor, Christof J. ; Magis-Escurra, Cecile ; van Ingen, Jakko ; Boeree, Martin J. ; van Soolingen, Dick
• Description:
  In the Netherlands, 1.4% of tuberculosis (TB) cases are caused by Mycobacterium bovis. After we admitted 3 patients with M. bovis infections to our reference hospital, we conducted a retrospective analysis of all M. bovis disease in the Netherlands during 1993-2007. We analyzed data from 231 patients for clinical, demographic, treatment, and outcome characteristics and for risk factors. Most patients were native Dutch (n = 138; 59.7%) or Moroccan (n = 54; 23.4%). Disease was mainly extrapulmonary (n = 136; 58.9%). Although 95 patients had pulmonary disease, person-to-person transmission did not occur, as shown by structural DNA fingerprinting analysis. Lymph node TB was more likely to develop in women (p<0.0001), whereas pulmonary M. bovis disease developed more frequently in men (p<0.0001). Diagnosis was accurate but delayed and led to inadequate treatment in 26% of the cases. Proportion of deaths from M. bovis disease was higher than that for M. tuberculosis disease.
• Subjects:
  • Research
  • Mycobacterium bovis
  • M. tuberculosis disease
  • tuberculosis and other mycobacteria
  • epidemiology
  • M. bovis
  • anti-TNF-α
  • extrapulmonary disease
  • gender differences
  • research
  More +
• Source:
  Emerg Infect Dis. 17(3):457-463.
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/18433/cdc_18433_DS1.pdf
• File Type:
  [PDF - 289.24 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:789fea4d159afe2d6db8a8e45c16a8f4aaff8ae968c9d63dcc30299f8ae8c39e