Carcinogenicity of beryllium: review of the literature.

Details

• Personal Author:
  Groth DH
• Description:
  Experimental findings that demonstrate the carcinogenic aspects of beryllium (7440417) are reviewed. Beryllium compounds were the first nonradioactive chemicals that were found to cause osteogenic sarcomas and the first to produce lung cancer by inhalation in animals. Eleven different authors have published articles demonstrating that osteogenic sarcomas can be produced in rabbits by intravenous injection of beryllium compounds. Six other authors have published articles concluding that pulmonary neoplasms may be induced in rats by inhalation exposures to and intratracheal injections of beryllium compounds. Lung cancer has been produced in monkeys after inhalation exposure to beryllium. In view of these findings, the author concludes that beryllium is a carcinogen in laboratory animals, and that all beryllium compounds should be considered potential carcinogens. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Carcinogens Laboratories Occupational Health Poisoning Respiratory Tract Diseases Safety
• Keywords:
  Air-contamination Carcinogenesis Exposure-methods Laboratory-animals Metallic-poisons NIOSH-Author Respiratory-system-disorders Tumorigenesis
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  56-62
• Volume:
  21
• Issue:
  1
• NIOSHTIC Number:
  nn:00093495
• Citation:
  Environ Res 1980 Feb; 21(1):56-62
• Contact Point Address:
  D. H. Groth, Pathology Section, Biological Support Branch, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a1e0de04371681b7cf88d1ab07e2c175308fcb2af527fff675abb779e00fa47533f99bd3736dc33fb62288e67ef9461094f2ec899b85643d0effbe52601ed24
• Download URL:
  https://stacks.cdc.gov/view/cdc/184328/cdc_184328_DS1.pdf
• File Type:
  [PDF - 622.25 KB ]