Antibody-independent complement activation by cardroom cotton dust.

Details

• Personal Author:
  Elliott JA ; Kutz SA ; Major, Pervis C. ; Olenchock, Stephen A. ; Pearson DJ
• Description:
  The potential of cardroom cotton dust to activate in vitro the complement cascade from nonsensitized human and guinea pig sera was investigated. Untreated or treated (chlorophyll free, reduced lipid content, lyophilized) cotton dust samples were incubated with serum aliquots. Both dusts consumed hemolytic complement and reduced the C3 complement, but the untreated dust was much more active than the treated dust. In all serum samples, the untreated dust consumed greater amounts of complement or complement components than the treated dust. The untreated dust had 58 times more endotoxin than the treated dust. The alternative pathway was identified as the source for complement activation. The authors suggest that the higher concentration of endotoxin in the untreated dust cannot account for the total complement consumed, even though endotoxin activation of the alternative pathway has been documented. Cotton dust inhalation in vivo may induce airway changes mediated by complement activation. [Description provided by NIOSH]
• Subjects:
  Blood Hazardous Substances Hematologic Tests Hypersensitivity Immune System Laboratories Occupational Health Respiratory Tract Diseases Safety Textile Industry
• Keywords:
  Blood-chemistry Cotton-textiles Immunoreaction Invitro-study Laboratory-animals NIOSH-Author Respiratory-system-disorders Sensitization Textile-mills Textile-workers Toxicity

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• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  405-414
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:00093194
• Citation:
  Environ Res 1979; 19(2):405-414
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e741f5bb03f50a353daef4f0995e66216e2f6674e0c06d78bede904dc62e2cf088af5259b47291970dfaed9fd70f4d5a8aed610dbb2b99b7b30fef0cda21e25
• Download URL:
  https://stacks.cdc.gov/view/cdc/184319/cdc_184319_DS1.pdf
• File Type:
  [PDF - 2.05 MB ]