HLA-A1 and coalworkers' pneumoconiosis.

Details

• Personal Author:
  Heise ER ; Kutz SA ; Major, Pervis C. ; Mentnech MS ; Merchant, James A. ; Morgan WK ; Olenchock, Stephen A.
• Description:
  The relationship between HLA antigen frequencies and coalworkers' pneumoconiosis was investigated in 358 coal miners from West Virginia and Pennsylvania. The subjects were matched for age and years in mining, and were divided into three groups: those with progressive massive fibrosis; with simple coalworker's pneumoconiosis; and with no radiographic evidence of disease. Blood samples were collected over 30 months, and over 140 antisera were used to make antigen definitions. Blood group also was determined. No differences in antigen frequency were observed between the group with massive fibrosis and the group with simple pneumoconiosis. When these two groups were combined, HLA-A1 was significantly lower than in the control group. The authors conclude that there was a weak negative correlation between HLA-A1 and coalworkers' pneumoconiosis. Further study is recommended to confirm this relationship. [Description provided by NIOSH]
• Subjects:
  Age Factors Blood Coal Coal Mining Genetics Hematologic Tests Histology Hypersensitivity Immune System Mining Occupational Health Radiation Respiratory Tract Diseases Safety

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• Keywords:
  Age-factors Analytical-methods Blood-chemistry Coal-mining Data-collection Immunity Miners NIOSH-Author Pathogens Radiography Respiratory-system-disorders Sensitization

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• ISSN:
  0003-0805
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  119
• Issue:
  6
• NIOSHTIC Number:
  nn:00092293
• Citation:
  Am Rev Respir Dis 1979 Jun; 119(6):903-908
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  True
• Source Full Name:
  American Review of Respiratory Disease
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d89bd502b12bd0146a0bf924b50dc3e011cd98784763698b6240140ed5bcb9a8a50bec58e3862fce5af51fc8036d0ac09a39f9e9d3de404f5c448fbeb88163e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/184292/cdc_184292_DS1.pdf
• File Type:
  [PDF - 381.97 KB ]