The role of precipitins in allergic lung disease.

Details

• Personal Author:
  Burrell R ; Law FW ; Olenchock, Stephen A.
• Description:
  Experimental models of hypersensitivity pneumonitis in rabbits were constructed to investigate the etiology of the disease. Depressed arterial oxygen (7782447) tensions, hemolytic complement activities, and platelet counts, followed by the challenge of unimmunized rabbits by aerosols containing Aspergillus spores were used to determine the effect of the humoral antibody on the pulmonary physiologic impairment. It was shown to depend on the immunization by antihuman serum albumin (HSA) serum. Passive immunization by large quantities of the serum led to no rabbit response to depressions in arterial oxygen tension following aerosol challenge with antigen. Active immunization did produce responses with diverse patterns of pulmonary impairment with time, but no correlation of these defects with the presence of precipitins could be made. [Description provided by NIOSH]
• Subjects:
  Body Fluids Cardiovascular Diseases Cardiovascular System Hypersensitivity Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Allergic-reactions Body-fluids Cardiopulmonary-system-disorders Lung-disorders Physiology
• ISSN:
  0024-3205
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  19
• NIOSHTIC Number:
  nn:00085714
• Citation:
  Life Sci 1978 May; 22(19):1685-1690
• Federal Fiscal Year:
  1978
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Life Sciences
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0e63f42f77d04af73a762fac6bb1a4e797199cd718d667ed2f0a04511181495ac6df328f163f7294417c0d5cbf6fe45dd725529254b8efcaecf80ec2b11391b
• Download URL:
  https://stacks.cdc.gov/view/cdc/184267/cdc_184267_DS1.pdf
• File Type:
  [PDF - 335.30 KB ]