Quinoline: conversion to a mutagen by human and rodent liver.

Details

• Personal Author:
  Hollstein M ; Talcott R ; Wei E
• Description:
  Quinoline (91225), a hepatocarcinogen in rats, and 23 quinoline derivatives were tested for mutagenic activity with the ames salmonella typhimurium assay. Quinoline (91225), 5-hydroxyquinoline (578676), and 8-hydroxyquinoline (148243) were mutagenic in strain TA-100 when Aroclor-1254 (11097691) induced rat (male outbred Sprague-Dawley) liver homogenate was present in the incubation mixture. Enzyme preparations from rats pretreated with p-448 dependent aryl-hydrocarbon hydroxylase (9037529) inducers (3- methylcholanthrene (MCA) (56495) and beta-naphthoflavone) and MCA treated responsive C57BL mice also metabolized quinoline to a mutagen, but phenobarbital (50066) and pregnenolone-16alpha- carbonitrile pretreatment did not yield active preparations. The mutagenicity of quinoline was blocked by the in-vitro addition of menadione (58275), butylated-hydroxytoluene (128370), alpha- naphthoflavone, vitamin A acetate, and glutathione (70188) to the test system. Depletion of glutathione by diethyl-maleate (141059) pretreatment in-vivo enhanced the mutagenic potential of the liver enzyme preparation. Mutagenic activity was correlated to the formation of water soluble quinoline metabolites, and it is suggested that the reactive quinoline intermediate is quinoline-2,3- epoxide. Microsomal enzymes isolated from human liver tissue, but not lung tissue, also converted quinoline to a mutagen. [Description provided by NIOSH]
• Subjects:
  Biochemistry Carcinogens Energy Metabolism Mutagens Occupational Health Safety Staff Development
• Keywords:
  Bacteria Enzymatic-reaction Industrial-chemicals Metabolism NIOSH-Grant NIOSH-Publication Preservatives Quinolines Training
• ISSN:
  0027-8874
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  405-410
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:00076983
• Citation:
  J Natl Cancer Inst 1978 Feb; 60(2):405-410
• Contact Point Address:
  Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
• CAS Registry Number:
  2,6-Di-tert-butyl-4-methylphenol (CAS RN 128-37-0) ; 3-Methylcholanthrene (CAS RN 56-49-5) ; 5-Hydroxyquinoline (CAS RN 578-67-6) ; 8-Hydroxyquinoline (CAS RN 148-24-3) ; Benzo[a]pyrene 3-monooxygenase (CAS RN 9037-52-9) ; Diethyl maleate (CAS RN 141-05-9) ; Glutathione (CAS RN 70-18-8) ; Menadione (CAS RN 58-27-5) ; PCB-1254 (CAS RN 11097-69-1) ; Phenobarbital (CAS RN 50-06-6) ; Quinoline (CAS RN 91-22-5)
• Federal Fiscal Year:
  1978
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19710701
• Source Full Name:
  Journal of the National Cancer Institute
• End Date:
  19820831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c17bcb79e2ad24fb12ca4899ab4bf8fd920c69b25c2f62de1a03a6f219344ca36bea93fbf5511a7e972d8ef729d704914d873a1dea2b289e358dcc0a3428bf35
• Download URL:
  https://stacks.cdc.gov/view/cdc/184224/cdc_184224_DS1.pdf
• File Type:
  [PDF - 568.88 KB ]