Chronic biological effects of methyl methacrylate vapor: I. Body and tissue weights, blood chemistries, and intestinal transit in the rat.

Details

• Personal Author:
  Benhayem S ; Gold M ; Hohenleitner FJ ; Kendall FM ; Landin WE ; Tansy MF
• Description:
  The effects upon body and tissue weights, various blood parameters, and intestinal transit time associated with chronic exposures of rats to monomeric methacrylate (80626) (MMA) vapor concentrations were investigated. The most remarkable and readily apparent phenomenon was the obvious lack of body fat in the group which had been exposed for 3 months to an MMA vapor concentration of 116ppm in air. It was determined that rats which have received a daily 8-hour exposure to 116ppm of MMA vapor for 6 months have significantly lower adiposity, as measured by the popliteal fat pad, than those of a similar group which have received sham exposures. It was also determined that protracted exposures to MMA vapor in this concentration were associated with a significant decrease in intestinal transit performance. Although cholesterol (57885), blood urea nitrogen, inorganic phosphate and serum glutamic-oxaloacetic- transaminase exhibited significant changes at 6 months post exposure, the differences were too small for interpretation. [Description provided by NIOSH]
• Subjects:
  Adipose Tissue Digestive System Digestive System Diseases Hazardous Substances Hematologic Diseases Hematologic Tests Occupational Health Safety Toxicology
• Keywords:
  Acrylics Adipose-tissue Biological-transport Blood-disorders Chronic-toxicity Fat-metabolism Gastrointestinal-system-disorders Grants-other Hematology NIOSH-Grant NIOSH-Publication

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  66-77
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:00070678
• Citation:
  Environ Res 1976 Feb; 11(1):66-77
• Contact Point Address:
  Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
• CAS Registry Number:
  2-Propenoic acid, 2-methyl-, methyl ester (CAS RN 80-62-6) ; Cholesterol (CAS RN 57-88-5)
• Federal Fiscal Year:
  1976
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Temple University, Philadelphia, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19740501
• Source Full Name:
  Environmental Research
• End Date:
  19810331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0091154689c74e03902c18a421aaab147313aac57c5969abbb168537802c35f5849a551c2c624ca8d096034c6c999bb471767cee581d1c03af95ac5519732784
• Download URL:
  https://stacks.cdc.gov/view/cdc/184161/cdc_184161_DS1.pdf
• File Type:
  [PDF - 5.50 MB ]