Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds.

Details

• Personal Author:
  Balcerska I ; Brzeznicka E ; Chmielnicka J ; Pietruszczak A
• Description:
  In the course of 14 weeks exposure to mercury (7439976) compounds, including MetHg (a fluid seed dressing), mercuric-chloride (7487947), ethyl mercuric-chloride (107277) and phenyl-mercuric- chloride (100561), in doses corresponding to 5 percent of the median lethal dose three times a week, enhanced levels of activity of malate-dehydrogenase and glucose-phosphate isomerase in blood serum were observed. After 7 weeks of exposure about a four fold increase of malate-dehydrogenase (9001643) and two to three fold enhancement of glucose-phosphate isomerase activities were found relative to controls. After 14 weeks of exposure to MetHg or ethyl mercuric- chloride, organic mercury was found in the liver at concentrations of 28.8 and 4 micrograms per gram of tissue, respectively. Inorganic mercury was found in the livers of animals given any of the compounds. [Description provided by NIOSH]
• Subjects:
  Blood Enzymes Hazardous Substances Hematologic Tests Mercury Occupational Health Safety
• Keywords:
  Blood-chemistry Enzyme-activity Grants-other NIOSH-Grant NIOSH-Publication Organo-mercury-compounds Toxic-substances
• ISSN:
  0007-4861
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  447-455
• Volume:
  17
• Issue:
  4
• NIOSHTIC Number:
  nn:00070047
• Citation:
  Bull Environ Contam Toxicol 1977 Apr; 17(4):447-455
• CAS Registry Number:
  Ethylmercury chloride (CAS RN 107-27-7) ; Malate dehydrogenase (NAD) (CAS RN 9001-64-3) ; Mercuric chloride (CAS RN 7487-94-7) ; Mercury (CAS RN 7439-97-6) ; Phenylmercury chloride (CAS RN 100-56-1)
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Peer Reviewed:
  True
• Source Full Name:
  Bulletin of Environmental Contamination and Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a2a60f05a6f1b96c8ac16fc9b077009152431d8065d7315a80d7d3c0c8aefef74f53816b347976c0aed478071891db383c71a894597bb9e770b5b6a5f2d3bfa9
• Download URL:
  https://stacks.cdc.gov/view/cdc/184160/cdc_184160_DS1.pdf
• File Type:
  [PDF - 400.85 KB ]