Comparative changes in serum enzyme levels in beryllium- or carbontetrachloride-induced liver necrosis.

Details

• Personal Author:
  Clary JJ ; Groth DH
• Description:
  The serum enzymes isocitric-dehydrogenase, lactic dehydrogenase, glutamic-pyruvic-transaminase, and glutamic-oxaloacetic- transaminase, and the liver enzyme acid phosphatase are used to evaluate the difference in the rat response to beryllium induced midzonal liver necrosis and carbon-tetrachloride induced centrilobular necrosis. Beryllium induced liver necrosis appears in many respects to be different from necrosis induced by carbon- tetrachloride, with a much longer time required for beryllium injected animals to exhibit a serum enzyme elevation. [Description provided by NIOSH]
• Subjects:
  Blood Enzymes Hazardous Substances Hematologic Tests Hydrocarbons Liver Metals Occupational Health Poisoning Safety
• Keywords:
  Berylliosis Blood-chemistry Chlorinated-hydrocarbons Enzyme-activity Light-metals Liver-disorders Metal-poisoning NIOSH-Author Toxic-substances
• ISSN:
  0037-9727
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  143
• Issue:
  4
• NIOSHTIC Number:
  nn:00028867
• Citation:
  Proc Soc Exp Biol Med 1973 Sep; 143(4):1207-1210
• CAS Registry Number:
  Alanine aminotransferase (CAS RN 9000-86-6) ; Aspartate aminotransferase (CAS RN 9013-64-3) ; Beryllium (CAS RN 7440-41-7) ; Carbon tetrachloride (CAS RN 56-23-5) ; Isocitrate dehydrogenase (CAS RN 9001-58-5) ; L-Lactate dehydrogenase (CAS RN 9001-60-9)
• Federal Fiscal Year:
  1973
• Peer Reviewed:
  True
• Source Full Name:
  Proceedings of the Society for Experimental Biology and Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d70c2ca422440df924ac279294c6aa7474e8c894fe356a14fd18eca6f939a7a57f3257fe556bd6cae210c6036381d942815f4abe7dcdf8b1253a66f1c5386cad
• Download URL:
  https://stacks.cdc.gov/view/cdc/183932/cdc_183932_DS1.pdf
• File Type:
  [PDF - 275.51 KB ]