Epidemiological studies of vinyl chloride health effects in the United States.

Details

• Personal Author:
  Falk H ; Waxweiler, Richard J.
• Description:
  Early results from three US epidemiological studies on vinyl- chloride (75014) workers are briefly reported. A death certificate search for all cases of hepatic angiosarcoma in the US for the years 1966 to 1973 shows angiosarcoma to be the largest group (35 percent of total hepatic sarcomas), and the 2:1 male to female ratio argues for occupational exposure. A supplemental intensive case finding effort shows about 240 cases occurred during 1964-1974. Examples of misdiagnosis and lack of occupational information are given. Another study shows that there are no significant differences between 130 polyvinyl-chloride (9002862) (PVC) polymerization workers and a similar group from a tire plant for any of six liver function tests. In addition, no cases of hepatic angiosarcoma were found among workers with more than 10 years work in the PVC polymerization plant. The third study of cohort mortality at four PVC polymerization plants shows a possible association between vinyl- chloride exposure and occurrence of lung cancer. However, the possibility is considered that some additional chemical exposure at these plants may be working together with vinyl-chloride to produce the effect. [Description provided by NIOSH]
• Subjects:
  Diagnosis Epidemiology Hazardous Substances Hydrocarbons Liver Morbidity Occupational Health Plastics Safety
• Keywords:
  Chlorinated-hydrocarbons Data-analysis Data-collection Etiology Hazards Incidence Information-systems Liver-disorders NIOSH-Author Plastics-industry Toxic-substances

  More +
• ISSN:
  0035-9157
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSCI - Division of Field Studies and Clinical Investigations
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  303-306
• Volume:
  69
• Issue:
  4
• NIOSHTIC Number:
  nn:00069634
• Citation:
  Proc R Soc Med 1976 Apr; 69(4):303-306
• CAS Registry Number:
  Poly(vinyl chloride) (CAS RN 9002-86-2) ; Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  True
• Source Full Name:
  Proceedings of the Royal Society of Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2ef48c3404ac624ba5a9a6bcebed946353da9d9973fd0b398f99327b8e268788bb4f909ef34fdec23cf06b3c02d6e3b0104d3b67a7eff4ca3d652748c361ee7c
• Download URL:
  https://stacks.cdc.gov/view/cdc/184144/cdc_184144_DS1.pdf
• File Type:
  [PDF - 811.49 KB ]