Granulocyte recruitment to airways exposed to endotoxin aerosols.

Details

• Personal Author:
  Halprin GM ; Hudson AR ; Kilburn KH ; McKenzie WN
• Description:
  Guinea-pigs were exposed to aerosols of Salmonella typhosa endotoxin for 2 to 4 hours, and white cells in blood and in bronchopulmonary lavage were counted at 2, 4, and 6 hours. The polymorphonuclear leukocyte counts in cardiac blood were significantly increased, and lymphocyte counts were decreased at 6 hours. The number of cells obtained by bronchopulmonary lavage, which were mostly polymorphonuclear leukocytes, increased at 4 hours to 28 million, and at 6 hours, was 26.5 million, compared to 5 million cells at the same times in air and in water aerosol control preparations. The polymorphonuclear cell counts on airway cross sections showed a mean peak of 53.9 after 4 hours in guinea pigs and a peak of 99.7 after 6 hours in hamsters. Alveoli showed no cell recruitment. Platelets were aggregated on surfaces of arterioles facing bronchioles, although counts in blood were unchanged. Neither leukocytes nor airway cells showed damage to their ultrastructure. The time course for airway recruitment and leukocytosis matches that for symptoms after exposure of workers to dusts from natural fodder or fibers. This suggests that leukocyte recruitment to airways by inhaled endotoxin may be part of the mechanism for the fever and chest tightness in occupational disorders. [Description provided by NIOSH]
• Subjects:
  Blood Dust Hazardous Substances Hematologic Tests Lung Occupational Diseases Occupational Health Poisoning Respiratory System Respiratory Tract Diseases Safety Toxicology

  More +
• Keywords:
  Blood-tests Dust-inhalation NIOSH-Grant NIOSH-Publication Occupational-diseases Organic-dusts Poisons Pulmonary-system Pulmonary-system-disorders Toxins Vegetable-dusts White-blood-cells

  More +
• ISSN:
  0003-0805
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Missouri ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  89-95
• Volume:
  115
• Issue:
  1
• NIOSHTIC Number:
  nn:00058906
• Citation:
  Am Rev Respir Dis 1977 Jan; 115(1):89-95
• Contact Point Address:
  Medicine University of Missouri N424 Medical Center Columbia, MO 65201
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Missouri Columbia, Columbia, Missouri
• Peer Reviewed:
  True
• Start Date:
  19730601
• Source Full Name:
  American Review of Respiratory Disease
• End Date:
  19800331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:639451981f4cccedb323c7358ad32eb9e996b1a5cd80c1820d3cc5da987a01abd87fec099144c35de16f1a077262fd4274fbf55e41bbeda75a46d0d01946bac7
• Download URL:
  https://stacks.cdc.gov/view/cdc/184121/cdc_184121_DS1.pdf
• File Type:
  [PDF - 644.62 KB ]