The role of precipitins and complement activation in the etiology of allergic lung disease.

Details

• Personal Author:
  Burrell R ; Olenchock, Stephen A.
• Description:
  An experimental model of allergic lung disease is described that is monitored by analysis of arterial oxygen tension following aerosol challenge with antigen. Rabbits immunized to a classical soluble antigen, human serum albumin, to the point where severe Arthus skin reactivity was demonstrable, were aerosol challenged with antigen. Arterial oxygen tension measurements made on prechallange and postchallenge samples yielded early, late, and continuous response patterns, reminiscent of those obtained in humans following provocation testing. Aerosol challenge of unimmunized animals resulted in no change from baseline conditions. Unimmunized rabbits exposed to small and massive aerosols of Aspergillus spores also demonstrated various postchallenge depressions in arterial oxygen tension as well as decreased levels in hemolytic complement activity, depending on the species of fungus and dose of spores used. Unimmunized animals pretreated with cobra venom factor in a manner known to achieve complement depletion failed to respond with altered arterial oxygen tensions following similar aerosol challenge. It is postulated that although precipitins may play a role in artificial disease initated by soluble antigen, nonspecific complement activation may be more important in understanding the etiology of spontaneous disease in humans brought about by inhalation of moldy particulate matter. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Antibodies Dust Fungi Hypersensitivity Immune System Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Skin Diseases

  More +
• Keywords:
  Airborne-particulates Allergic-reactions Blood-gases Dust-inhalation Immunity Immunological-tests Respiratory-disorders Serological-analysis Skin-disorders
• ISSN:
  0091-6749
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  76-88
• Volume:
  58
• Issue:
  1
• NIOSHTIC Number:
  nn:00057305
• Citation:
  J Allergy Clin Immunol 1976 Jul; 58(1)(1):76-88
• Federal Fiscal Year:
  1976
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Part Number:
  1
• Start Date:
  19710601
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:da420082c208ccc8185e916d464fb972a34f7921879686fa1224836aa5c6127e8bd9d150a92abacab5d04592f9eb82719a351cc9b379b553f06ac5389d729d37
• Download URL:
  https://stacks.cdc.gov/view/cdc/184115/cdc_184115_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]