Uptake of mercury and mercury-amino acid complexes by rat renal cortex slices.

Details

• Personal Author:
  Murphy SD ; Richardson RJ ; Wilder AC
• Description:
  The effects of metabolism and complexes with amino acids on the renal uptake of mercury are determined using rat renal cortex slices. Mercury (7439976) levels in the slices after 1 hour of incubation are 50 percent higher with mercuric cysteine than with mercuric-chloride (7487947). The enhanced uptake of mercuric cysteine is reduced in the presence of an excess of lysine (56871) or histidine (71001), with dinitrophenol (51285) present, at 25 degrees or in anaerobic conditions. The uptake of mercuric cysteine is unaffected by serine and increased by cysteine (52904). The metabolic conditions do not affect the uptake of mercuric chloride, suggesting that a portion of the renal uptake of mercury operates through amino acid transport mechanisms acting on mercury-amino acid complexes. [Description provided by NIOSH]
• Subjects:
  Mercury Metals, Heavy Occupational Health Safety
• Keywords:
  Grants-other Heavy-metals Kidney Mercury-compounds NIOSH-Grant NIOSH-Publication Nitrophenols Organo-mercury-compounds
• ISSN:
  0037-9727
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  303-307
• Volume:
  150
• Issue:
  2
• NIOSHTIC Number:
  nn:00054035
• Citation:
  Proc Soc Exp Biol Med 1975 Apr; 150(2):303-307
• Contact Point Address:
  Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
• CAS Registry Number:
  2,4-Dinitrophenol (CAS RN 51-28-5) ; L-(+)-Cysteine (CAS RN 52-90-4) ; L-Histidine (CAS RN 71-00-1) ; L-Lysine (CAS RN 56-87-1) ; Mercuric chloride (CAS RN 7487-94-7) ; Mercury (CAS RN 7439-97-6)
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Proceedings of the Society for Experimental Biology and Medicine
• End Date:
  19810430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6907aa3b0ce05a238e06715af2980cb0f8687a8a243952caa2b1b3bb34a76f54981f996a5b6242b63ffa7e21156a26a2bcf56a1a939ed61d738e2c1248cb489d
• Download URL:
  https://stacks.cdc.gov/view/cdc/184090/cdc_184090_DS1.pdf
• File Type:
  [PDF - 445.62 KB ]