Leukocyte recruitment to airways by cigarette smoke and particle phase in contrast to cytotoxicity of vapor.

Details

• Personal Author:
  Kilburn KH ; McKenzie W ; Kilburn KH ; McKenzie W
• Description:
  The immediate effects of airborne exposure to vapor or particle phase of unfiltered whole cigarette smoke is studied in hamsters. Airways of hamster lungs show recruitment of polymorphonuclear leukocytes after breathing fresh cigarette smoke in a miniature chamber. Exposure to particles alone by removal of the vapor phase with charcoal does not change the leukocyte response. However, exposure to cigarette smoke vapor after removal of particles with Cambridge filters does not recruit leukocytes but produces nuclear and cytoplasmic vacuoles, double nuclei, and exfoliation of cells. The main agents responsible for the vapor toxicity are suggested to be nitrogen-dioxide (10102440) and formaldehyde (50000). [Description provided by NIOSH]
• Subjects:
  Aldehydes Cytology Cytotoxins Formaldehyde Nitrogen Oxides Occupational Health Respiratory Tract Diseases Safety Smokers Tobacco Products
• Keywords:
  Cytopathology Cytotoxicity NIOSH-Grant NIOSH-Publication Nitrogen-oxides Pulmonary-system-disorders Smoking Tobacco-constituents
• ISSN:
  0036-8075
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Missouri ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  189
• Issue:
  4203
• NIOSHTIC Number:
  nn:00051625
• Citation:
  Science 1975 Aug; 189(4203):634-627
• Contact Point Address:
  Medicine University of Missouri N424 Medical Center Columbia, MO 65201
• CAS Registry Number:
  Formaldehyde (CAS RN 50-00-0) ; Nitrogen dioxide (CAS RN 10102-44-0) ; Formaldehyde (CAS RN 50-00-0) ; Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Pulmonary System Disorders ; Pulmonary System Disorders
• Performing Organization:
  University of Missouri Columbia, Columbia, Missouri
• Peer Reviewed:
  True
• Start Date:
  19730601
• Source Full Name:
  Science
• End Date:
  19800331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:03638d58b372bb617c43be7dceb14bd7f2e5c603f488bc3e8607df0cc68dd428ac188c3489c74dbe86f72a21702f89beb796f49ccd90cb732b0fdfea3c04aea0
• Download URL:
  https://stacks.cdc.gov/view/cdc/184064/cdc_184064_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]