Growth hormone responses to L-dopa in depressed patients.

Details

• Personal Author:
  Mushrush G ; Perlow M ; Sachar EJ ; Sassin J ; Weitzman ED
• Description:
  Plasma human growth hormone responses to oral administration of 500 milligrams of L-dopa (59927) are analyzed in three groups of subjects: normals age 20-32; normals age 48-68; and unipolar depressed patients, age 45 to 68. While only 7 percent of the young normals have deficient human growth hormone responses to this stimulus, 36 percent of the older normals and 77 percent of the depressed patients fail to have adequate responses, suggesting an effect of age and a further effect of depressive illness. Because the release of human growth hormone appears to be closely related to brain catecholamine metabolism, the deficient responses in the depressed patients may provide further support to the concept of a neurochemical defect in depressive illness. [Description provided by NIOSH]
• Subjects:
  Amines Occupational Health Safety
• Keywords:
  Drugs Grants-other Hormone-metabolism NIOSH-Grant NIOSH-Publication
• ISSN:
  0036-8075
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  178
• Issue:
  4067
• NIOSHTIC Number:
  nn:00038654
• Citation:
  Science 1972 Dec; 178(4067):1304-1305
• Contact Point Address:
  Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
• CAS Registry Number:
  DOPA (CAS RN 59-92-7)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Montefiore Hospital and Medical Center, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Science
• End Date:
  19761231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e90cf360d2e0933f31f2cb418060cf3fc8756ecb05ddd5abfda28db155d6c49db05b30af1a19b7602c1fb3e634ddac8e8a61e31bf4efd0d42ab7114840b71b91
• Download URL:
  https://stacks.cdc.gov/view/cdc/183996/cdc_183996_DS1.pdf
• File Type:
  [PDF - 480.51 KB ]