Modification of acrylamide neuropathy in rats by selected factors.

Details

• Personal Author:
  Gilles FH ; Kaplan ML ; Murphy SD
• Description:
  A modified rotarod technique is used to determine if dietary deficiencies in pyridoxine (65236) or thiamine (59438), bilateral adrenalectomy or cortisol (50237) treatment and pretreatment with microsomal enzyme inducers (DDT (50293) or phenobarbital (57307)) would modify the course of onset and recovery from functional acrylamide neuropathy in rats. Neither pyridoxine nor thiamine deficiency nor daily injections of cortisol is found to have any measurable effect on the cumulative dose of acrylamide required to produce functional impairment. Histologic studies of peripheral nerves from acrylamide treated rats reveal that at the time of onset of functional impairment young and phenobarbital pretreated adult rats have severe peripheral nerve damage. The total cumulative doses of acrylamide required to produce neurologic deficit in DDT pretreated and phenobarbital pretreated rats are 520 and 600 milligrams per kilogram, respectively, compared to 360 milligrams per kilogram for the controls. [Description provided by NIOSH]
• Subjects:
  Adrenal Cortex Hormones Amides Amines Endocrine System Nervous System Nervous System Diseases Occupational Health Pyridines Safety
• Keywords:
  Adrenal-cortex Adrenal-gland-disorders Adrenocortical-hormones Corticoids Drugs Endocrine-system Grants-other Neurological-diseases NIOSH-Grant NIOSH-Publication Vitamins

  More +
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  4
• NIOSHTIC Number:
  nn:00023608
• Citation:
  Toxicol Appl Pharmacol 1973 Apr; 24(4):564-579
• Contact Point Address:
  Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
• CAS Registry Number:
  Cortisol (CAS RN 50-23-7) ; DDT (CAS RN 50-29-3) ; Phenobarbital sodium (CAS RN 57-30-7) ; Pyridoxine (CAS RN 65-23-6) ; Vitamin B1 (CAS RN 59-43-8)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19710101
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19810430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:247826f64598004e3e6f27cef17cd3b10c8a00a9bf5ed5f34a6da552da5f33aa856478ba8a9d484b96e9b36e14dcc5e3468f9882d07bb02d3dd2c48a18477db7
• Download URL:
  https://stacks.cdc.gov/view/cdc/183859/cdc_183859_DS1.pdf
• File Type:
  [PDF - 2.30 MB ]