"Nonspecific" interstitial pulmonary fibrosis: association with asbestos fibers detected by electron microscopy.

Details

• Personal Author:
  Langer AM ; Miller, Aubrey K. ; Selikoff IJ ; Teirstein AS
• Description:
  The case history is described of a 63 year old clerk with ventilatory alterations and evidence of diffuse honeycombing, in whom electron microscopy of a lung biopsy specimen demonstrated the presence of a large number of very small chrysotile (12001295) asbestos fibers. The case reported documents the association of submicroscopical chrysotile fibrils with severe pulmonary fibrosis, in the absence of fibers demonstrable by light microscopy. The asbestos content of the patient's lung was calculated to be a minimum 0.45 grams, an amount consistent with a low level occupational exposure. [Description provided by NIOSH]
• Subjects:
  Asbestos Dust Inorganic Chemicals Lung Occupational Health Particulate Matter Radiation Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Asbestos-dust Asbestosis Fibrogenic-dusts Histopathology Lung-fibrosis Particle-size-distribution Pulmonary-system-disorders Radiology Respiratory-functions Respiratory-system-disorders
• ISSN:
  0028-4793
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-93
• Volume:
  292
• Issue:
  2
• NIOSHTIC Number:
  nn:00038208
• Citation:
  N Engl J Med 1975 Jan; 292(2):91-93
• Contact Point Address:
  Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
• CAS Registry Number:
  Chrysotile (CAS RN 12001-29-5)
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19700501
• Source Full Name:
  New England Journal of Medicine
• End Date:
  19790630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d046ad9f7bcfff9c828985dab30f812a7f2c7f96aa6fa0b3c7f0f6aa7f9a0087591fa85ef34a1253588b3b63e1453e2dfa60479c19255dd3ea6048e59057576
• Download URL:
  https://stacks.cdc.gov/view/cdc/183987/cdc_183987_DS1.pdf
• File Type:
  [PDF - 2.48 MB ]