Are trace metals associated with asbestos fibers responsible for the biologic effects attributed to asbestos?

Details

• Personal Author:
  Cralley LJ ; Lainhart WS
• Description:
  The role of trace metals associated with asbestos (1332214) in relation to the biologic response to asbestos is evaluated by reviewing the predominant biologic responses to asbestos and the pathogenic mechanisms involved, identifying the trace metals associated with different types of asbestos, and presenting evidence relating the response to the presence of trace metals. Data are given for the comparative levels of nickel (7440020), chromium (7440473), cobalt (7440484), and manganese (7439965) in different size factors of mine milled chrysotile (12001295), crocidolite (12001284), amosite (12172735), and anthophyllite (17068789), and also for tumors observed at site of injection after 17 months in rats. Results do not indicate any definitive evidence that relates the fibrogenic properties of asbestos fibers or their potential to form asbestos bodies to trace metals associated with the fibers, but suggest that the electromotive interactions of the metals and minerals present are important determinants in the carcinogenic action of asbestos. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dust Lung Lung Diseases Metals Neoplasms Occupational Health Poisoning Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Fibrous-dusts JOCMA7 Lung-cancer Metal-poisoning Metallic-dusts Mineral-dusts NIOSH-Author Physiological-effects Reactive-dusts Respirable-dusts Respiratory-system-disorders Trace-elements

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• ISSN:
  0096-1736
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  262-266
• Volume:
  15
• Issue:
  3
• NIOSHTIC Number:
  nn:00023959
• Citation:
  J Occup Med 1973 Mar; 15(3):262-266
• CAS Registry Number:
  Amosite asbestos (CAS RN 12172-73-5) ; Anthophyllite (CAS RN 17068-78-9) ; Asbestos (CAS RN 1332-21-4) ; Chromium (CAS RN 7440-47-3) ; Chrysotile (CAS RN 12001-29-5) ; Cobalt (CAS RN 7440-48-4) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:58110c6632848548983e2618d201e90ff4e28d80770f52e7ffb5592b9a4a3e66ff5a186e68253a236086f063fa3a4abff81120e18ebc6a18c46a7919253e9aee
• Download URL:
  https://stacks.cdc.gov/view/cdc/183879/cdc_183879_DS1.pdf
• File Type:
  [PDF - 2.37 MB ]