Responses of alveolar macrophages to metals I. Inhalation of lead and nickel.

Details

• Personal Author:
  Barkley W ; Bingham E ; Stemmer K ; Taylor, Philip R. ; Zerwas M
• Description:
  Histopathological examination of lungs by light microscopy, and measurement of the number of alveolar microphages available by a standard washing procedure, for animals subjected to inhalation of soluble and insoluble aerosols of lead or nickel, Pb-C12, Pb2-03, Ni- C12, and NiO, near or below the levels proposed as acceptable for occupational exposures. The number of available macrophages increased for NiO, decreased for Pb2-03, and was not changed for Pb- Cl2, and Ni-Cl1. However, distribution in cell sizes varied with exposure. Observed histopathological changes from nickel compounds are cited as requiring a lowering of the threshold limit value for nickel and nickel compounds. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cytology Metals Occupational Health Particulate Matter Poisoning Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Air-contaminants Airborne-particles Metal-poisoning NIOSH-Grant NIOSH-Publication Physiological-effects Respiratory-system-disorders TLV
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  406-414
• Volume:
  25
• Issue:
  6
• NIOSHTIC Number:
  nn:00012204
• Citation:
  Arch Environ Health 1972 Dec; 25(6):406-414
• Contact Point Address:
  Environmental Health University of Cincinnati College of Medicine Cincinnati, Ohio 45219
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead chloride (CAS RN 7758-95-4) ; Nickel (CAS RN 7440-02-0) ; Nickel dichloride (CAS RN 7718-54-9) ; Nickel monoxide (CAS RN 1313-99-1)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19750831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07673497f9c193cc2b8448cf65eb0e2dfcbc6fc22213a0bd395f0ba833c05c55febd46a9df0a3c604cbd4d6da67e2dfa42001c55cf769fc994ea9aba5487d93d
• Download URL:
  https://stacks.cdc.gov/view/cdc/183784/cdc_183784_DS1.pdf
• File Type:
  [PDF - 7.05 MB ]