Experimental asbestos carcinogenesis.

Details

• Personal Author:
  Puro HE ; Reeves AL ; Smith RG ; Vorwald AJ
• Description:
  Laboratory rodents were exposed to one of three mineralogical types of asbestos dust amosite, crocidolite, or chrysotile. Inhalation exposures were accompalished in chambers where ballmilled specimens of these dusts were disseminated for 4 hours daily, 4 days weekly. Additional animals were injected with these dusts intratracheally, intrapleurally, or intraperitoneally. Histopathologic studies showed a fibrotic reaction in all species to all three types of dusts, with amosite provoking the strongest such response especially in guinea pigs. Two pulmonary cancers were produced in rats exposed to the inhalation of crocidolite. Local injection into the pleural or peritoneal cavities caused 5 mesotheliomas in rats after chrysotile treatment and 6 meotheliomas in rats and rabbits after crocidolite treatment. Guinea pigs and hamsters developed no tumors in this experiment, and with the dose used, there were no tumors in any species in the amosite group. [Description provided by NIOSH]
• Subjects:
  Asbestos Carcinogens Dust Inorganic Chemicals Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Asbestos-dusts Carcinogenesis Dust-inhalation Lung-cancer Lung-fibrosis NIOSH-Grant NIOSH-Publication Respiratory-disorders
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  496-511
• Volume:
  4
• Issue:
  6
• NIOSHTIC Number:
  nn:00012058
• Citation:
  Environ Res 1971 Dec; 4(6):496-511
• Contact Point Address:
  Occupational & Environ Health Wayne State University 625 Mullett Detroit, Mich 48226
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5) ; Crocidolite asbestos (CAS RN 12001-28-4)
• Federal Fiscal Year:
  1972
• Performing Organization:
  Wayne State University, Detroit, Michigan
• Peer Reviewed:
  True
• Start Date:
  19700601
• Source Full Name:
  Environmental Research
• End Date:
  19770731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e66c5f7bd0171c97462b3a16d3516785dde7e5013e89768def9e533c0fb189b7060460c4564aa63facbddd15c0c83351e8e84a3b8af699a0fd0ff4e12f4b001a
• Download URL:
  https://stacks.cdc.gov/view/cdc/183778/cdc_183778_DS1.pdf
• File Type:
  [PDF - 10.55 MB ]