Diseases Caused by Asbestos: Mechanisms of Injury and Disease Development

Details

• Personal Author:
  Manning CB ; Mossman BT ; Vallyathan V
• Description:
  Asbestos is a ubiquitous, naturally occurring fiber that has been linked to the development of milgnant and fibrotic disease of the lung and pleura. These diseases may be initiated by injury to epithelial cells and mesthelial cells by asbestos fibers through the formation of reactive oxygen intermediates. Elaboration of oxdants are also a consequence of inflammation, a hallmark of exposure to asbestos after inhalation or injection of asbestos fibers into animals. The type, size, and durability of asbestos fibers may be important in toxicity and pathogenicity of asbestos types. This review discusses the pathways of oxidant generation by asbestos fibers, cell-cell interaction that may initiate and perpetuate inflammation, cytokine release and proliferative responses to asbestos, and cell signaling pathways implicated in these events. [Description provided by NIOSH]
• Subjects:
  Animals Asbestos Carcinogens Dust Epidemiology Fibrosis Inorganic Chemicals Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Animal-studies Asbestos-cement Asbestos-dust Asbestos-fibers Asbestosis Author Keywords: Asbestos Bronchial-cancer Cancer Carcinogenesis Fibrogenesis Fibrogenicity Lung-cancer Lung-disease Lung-disorders Lung-fibrosis Lung-irritants Mesothelial-cells NF-kB Pleural-cavity Pulmonary-cancer Pulmonary-disorders Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  1567-5769
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 1 ; OSHA Region 3 ; Vermont ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  191-200
• Volume:
  2
• Issue:
  2
• NIOSHTIC Number:
  nn:20027222
• Citation:
  Int Immunopharmacol 2002 Feb; 2(2-3):191-200
• Contact Point Address:
  Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  bmossman@zoo.uvm.edu
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  International Immunopharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3a3a8fb3c89a40af01b5e8f06e2157e32b94242928de4e887d3e87113b3919b1b6251689ea3f4cb82f38f74a660794140ffe935f43300abae0f08cf66e6b3ea
• Download URL:
  https://stacks.cdc.gov/view/cdc/197511/cdc_197511_DS1.pdf
• File Type:
  [PDF - 153.68 KB ]