Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Cao, Cunwei ; Liang, Ling ; Wang, Wenjuan ; Luo, Hong ; Huang, Shaobiao ; ... More +
Cao, Cunwei ; Liang, Ling ; Wang, Wenjuan ; Luo, Hong ; Huang, Shaobiao ; Liu, Donghua ; Xu, Jianping ; Henk, Daniel A. ; Fisher, Matthew C. ; Less -
Description:
Human penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June 2004-July 2005 across Guangxi Province, China, and demonstrated 100% prevalence of infection. Multilocus genotypes show that P. marneffei isolates from humans are similar to those infecting rats and are in some cases identical. Comparison of our dataset with genotypes recovered from sites across Southeast Asia shows that the overriding component of genetic structure in P. marneffei is spatial, with humans containing a greater diversity of genotypes than rodents. Humans and bamboo rats are sampling an as-yet undiscovered common reservoir of infection, or bamboo rats are a vector for human infections by acting as amplifiers of infectious dispersal stages.
Subject:
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Animals
Disease Reservoirs
Genotype
Humans
Mycoses
Penicillium
Prevalence
Research
Rodent Diseases
Rodentia

Source:
Emerg Infect Dis. 17(2):209-214. ;
Document Type:
Journal Article ;
Place as Subject:
China ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:2aae1de7895a962e7ec3bb87dd31fe90cc8bfa6a13192ea1f9aad2c69ac7a5aa
File Type:

Supporting Files

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