Oral Fluid Testing during 10 Years of Rubella Elimination, England and Wales

Manikkavasagan, Gayatri; Bukasa, Antoaneta; Brown, Kevin E.; Cohen, Bernard J.; Ramsay, Mary E.

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Oral Fluid Testing during 10 Years of Rubella Elimination, England and Wales

Supporting Files Public Domain

Oct 2010
By Manikkavasagan, Gayatri ; Bukasa, Antoaneta ; Brown, Kevin E. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Manikkavasagan, Gayatri ; Bukasa, Antoaneta ; Brown, Kevin E. ; Cohen, Bernard J. ; Ramsay, Mary E.
Description:

Surveillance of rubella in England and Wales has included immunoglobulin M testing of oral (crevicular) fluid from reported case-patients since 1994. The need for laboratory confirmation to monitor rubella elimination is emphasized by poor sensitivity (51%, 95% confidence interval 48.9%-54.0%) and specificity (55%, 95% confidence interval 53.7%-55.6%) of the clinical case definition. During 1999-2008, oral fluid from 11,709 (84%) of 13,952 reported case-patients was tested; 143 (1.0%) cases were confirmed and 11,566 (99%) were discarded (annual investigation and discard rate of clinically suspected rubella cases was 2,208/100,000 population). Incidence of confirmed rubella increased from 0.50 to 0.77/1 million population when oral fluid testing was included. Oral fluid tests confirmed that cases were more likely to be in older, unvaccinated men. Testing of oral fluid has improved ascertainment of confirmed rubella in children and men and provided additional information for assessing UK progress toward the World Health Organization elimination goal.
Subjects:

Adolescent Adult Age Distribution Child Child, Preschool Disease Elimination England Female Gingival Crevicular Fluid Humans Immunoglobulin M Incidence Infant Male Oral Fluid Testing Population Surveillance Research Rubella Rubella Virus Sensitivity Sensitivity And Specificity Sex Distribution Specificity Viruses Wales Young Adult
Source:

Emerg Infect Dis. 16(10):1532-1538.
Document Type:

Journal Article
Volume:

16
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:eccacb7147c704555d8404899670b653a7ab1b4acb7bec6e3f794494955e4641
Download URL:

https://stacks.cdc.gov/view/cdc/18324/cdc_18324_DS1.pdf
File Type:

[PDF - 323.52 KB ]

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