Molecular Epidemiology of Fonsecaea Species

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Najafzadeh, Mohammad Javad ; Sun, Jiufeng ; Vicente, Vania A. ; Klaassen, Corne H.W. ; Bonifaz, Alexandro ; van den Ende, A.H.G. Gerrits ; Menken, Steph B.J. ; Sybren de Hoog, G.
• Description:
  To assess population diversities among 81 strains of fungi in the genus Fonsecaea that had been identified down to species level, we applied amplified fragment-length polymorphism (AFLP) technology and sequenced the internal transcribed spacer regions and the partial cell division cycle, beta-tubulin, and actin genes. Many species of the genus Fonsecaea cause human chromoblastomycosis. Strains originated from a global sampling of clinical and environmental sources in the Western Hemisphere, Asia, Africa, and Europe. According to AFLP fingerprinting, Fonsecaea isolates clustered in 5 groups corresponding with F. pedrosoi, F. monophora, and F. nubica: the latter 2 species each comprised 2 groups, and F. pedrosoi appeared to be of monophyletic origin. F. pedrosoi was found nearly exclusively in Central and South America. F. monophora and F. nubica were distributed worldwide, but both showed substantial geographic structuring. Clinical cases outside areas where Fonsecaea is endemic were probably distributed by human migration.
• Subjects:
  Actins Amplified Fragment Length Polymorphism Analysis Ascomycota DNA, Fungal DNA, Ribosomal Spacer Environmental Microbiology Female Global Health Humans Male Molecular Epidemiology Mycological Typing Techniques Research Species Specificity Tubulin

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• Source:
  Emerg Infect Dis. 17(3):464-469.
• Document Type:
  Journal Article
• Volume:
  17
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9a5cc5bf857d0a40822bf36746d3617fd20821983e11a84e866017bb56be25d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/18323/cdc_18323_DS1.pdf
• File Type:
  [PDF - 283.68 KB ]