Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore

Chen, Mark I.C.; Lee, Vernon J.M.; Barr, Ian; Lin, Cui; Goh, Rachelle; Lee, Caroline; Singh, Baldev; Tan, Jessie; Lim, Wei-Yen; Cook, Alex R.; Ang, Brenda; Chow, Angela; Tan, Boon Huan; Loh, Jimmy; Shaw, Robert; Chia, Kee Seng; Lin, Raymond T.P.; Leo, Yee Sin

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Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore

Supporting Files Public Domain

Oct 2010
By Chen, Mark I.C. ; Lee, Vernon J.M. ; Barr, Ian ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Chen, Mark I.C. ; Lee, Vernon J.M. ; Barr, Ian ; Lin, Cui ; Goh, Rachelle ; Lee, Caroline ; Singh, Baldev ; Tan, Jessie ; Lim, Wei-Yen ; Cook, Alex R. ; Ang, Brenda ; Chow, Angela ; Tan, Boon Huan ; Loh, Jimmy ; Shaw, Robert ; Chia, Kee Seng ; Lin, Raymond T.P. ; Leo, Yee Sin
Description:

We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October 2009, with seroconversion defined as a ≥4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95% CI 1.3-15.6). Contact with pandemic (H1N1) 2009-infected colleagues (aOR 2.5, 95% CI 0.9-6.6) and larger household size (aOR 1.2, 95% CI 1.0-1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.
Subjects:

Adult Antibodies, Viral Disease Outbreaks Female Humans Incidence Influenza, Human Influenza A Virus, H1N1 Subtype Male Occupational Exposure Pandemics Personnel, Hospital Risk Factors Seroepidemiologic Studies
Source:

Emerg Infect Dis. 16(10):1554-1561.
Document Type:

Journal Article
Place as Subject:

Singapore
Volume:

16
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:5d5916d940c230d0ba58f62cea1095242d293d8e844b3b2556246bfb4e61ad5d
Download URL:

https://stacks.cdc.gov/view/cdc/18317/cdc_18317_DS1.pdf
File Type:

[PDF - 222.11 KB ]

File Language:

English

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