Scientific considerations for potential addition of uterine cancer to the list of covered conditions by the World Trade Center Health Program (revised).

Details

• Personal Author:
  WTC Health Program
• Description:
  The World Trade Center (WTC) Health Program provides medical monitoring and treatment benefits for health conditions on the List of WTC-Related Health Conditions (the List). The List currently includes aerodigestive disorders, mental health conditions, musculoskeletal disorders, and cancers. The List was established in the Zadroga Act and new health conditions may be added to the List by rulemaking. In addition to the Program's regulatory provisions in 42 C.F.R. Part 88, the WTC Health Program Policy and Procedures for Adding Types of Cancer to the List of WTC-Related Health Conditions governs the evaluation of evidence supporting the potential addition of a type of cancer to the List. Uterine cancer is currently the only type of cancer not included in the WTC Health Program's List of WTC-Related Conditions. In September 2020, the WTC Health Program received a submission to add uterine cancer to the List. The medical basis for the submission was the contributing role of endocrine disrupting chemicals (EDCs) on the incidence rate of uterine cancers. Although this submission did not meet the Program's petition requirements, the Administrator instructed WTC Health Program staff to review the evidence for uterine carcinogenicity by EDCs and other 9/11 agents. This document provides the WTC Health Program's assessment of the currently available evidence to support adding uterine cancer to the List. In addition to directing the Science Team to assess the available evidence supporting the addition of uterine cancer to the List, the Administrator is seeking the advice of the Scientific/Technical Advisory Committee (STAC) for a recommendation regarding whether there is a reasonable basis for adding uterine cancer to the List. The STAC is given up to 180 days to provide the recommendation. The Administrator will evaluate the STAC's advice and will take an appropriate action not later than 90 days after receipt of the recommendation. Changes to the revised version of the white paper include: 1) Summaries of three additional studies on 9/11 exposures and cancer (Boffetta et al. [2016], Shapiro et al. [2020], and Li et al. [2021]). 2) Table 2 and the corresponding study summaries are organized by study design and year of publication. 3) 3,3',4,4',5-Pentachlorobiphenyl is listed as an IARC Group 1 carcinogen on Table 3. It has also been added to the list of carcinogenic endocrine disruptors listed on page 30. 4) Summaries of two additional studies on asbestos exposure and uterine cancer (Germani et al. [1999] and Magnani et al. [1993]). In addition, clarification was provided that the study by Magnani et al. [2007] was likely to include uterine and cervical cancer cases combined. 5) URLs and minor corrections on some references. None of these additions and changes affected the conclusions of the original White Paper.
• Subjects:
  Accidents, Occupational Dust Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Preceptorship Safety
• Keywords:
  Carcinogens Chemicals Endocrine Disruptors Health Promotion Uterine Cancer Uterus World Trade Center WTC
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Other
• Place as Subject:
  District of Columbia ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  WTCHP - World Trade Center Health Program
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-36
• NIOSHTIC Number:
  nn:20064662
• Citation:
  Washington, DC: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2021 Sep; :1-36
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6bdae84ed6f844df6703933d19ccffab8031b330b8396380ce11879794614dcd158a8d806c0b4779af987c4a6ac7518a57380a560395fb29e352a194f6402a26
• Download URL:
  https://stacks.cdc.gov/view/cdc/181944/cdc_181944_DS1.pdf
• File Type:
  [PDF - 1.96 MB ]