TERT and BRAF V600E Mutations in Thyroid Cancer of World Trade Center Responders

Details

• Personal Author:
  Brody R ; Cerutti JM ; Genden E ; Mendes TB ; Riggins GJ ; Taioli E ; Van Gerwen M
• Description:
  The 2-fold excess thyroid cancer risk reported in multiple World Trade Center (WTC) disaster exposed cohorts cannot entirely be explained by surveillance and physician bias thus highlighting the need to investigate the potential consequences of the dust exposure, containing carcinogenic and endocrine disruptive elements, on the thyroid. This study investigated the presence of TERT promoter and BRAF V600E mutations in 20 WTC-exposed versus 23 matched non-exposed thyroid cancers as potential mechanism explaining the excess risk. Although no significant difference in BRAF V600E mutation was found, TERT promoter mutations were significantly more prevalent in WTC thyroid cancer versus non-exposed thyroid cancers (P = 0.021). The odds of a TERT promoter mutation was significantly higher in the WTC versus the non-WTC thyroid cancers after adjustment [ORadj: 7.11 (95% CI: 1.21-41.83)]. These results may indicate that exposure to the mixture of pollutants present in the WTC dust resulted in an excess thyroid cancer risk and potentially more aggressive thyroid cancer, warranting investigating WTC responders on thyroid-associated symptoms during their health checkups. Future studies should include long-term follow-up to provide important insights in whether thyroid-specific survival is negatively affected by WTC dust exposure and whether this is because of the presence of one or more driver mutations. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dust Emergency Responders Endocrine System Genetics Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Cancer Carcinogenesis Dust Exposure Endocrine Disruptors Etiology First Responders Mutation Surveillance Thyroid Gland Disorders World Trade Center WTC

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• ISSN:
  0143-3334
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  350-355
• Volume:
  44
• Issue:
  4
• NIOSHTIC Number:
  nn:20067873
• Citation:
  Carcinogenesis 2023 Apr; 44(4):350-355
• Contact Point Address:
  Emanuela Taioli, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
• Email:
  Emanuela.Taioli@mountsinai.org
• Federal Fiscal Year:
  2023
• Performing Organization:
  Icahn School of Medicine at Mount Sinai
• Peer Reviewed:
  True
• Start Date:
  20190701
• Source Full Name:
  Carcinogenesis
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c619a7b0bf6d5761a0921b3606678fa9dea1dcf986a84ba09a00e7f81afc9cfbdab8ed483ac32824469ea1b428cd25822c1b683bdde0eaf2031586fbe244d0bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/230112/cdc_230112_DS1.pdf
• File Type:
  [PDF - 780.72 KB ]