An animal model to predict the pulmonary response to inhalation of agricultural dusts.

Details

• Personal Author:
  Castranova, Vince ; Frazer DG ; Jones U ; Robinson V ; Castranova, Vince ; Frazer DG ; Jones U ; Robinson V
• Description:
  Agricultural dusts are associated with many farm operations such as grain unloading, hay handling, chicken or pig confinement, etc. Such dusts are often contaminated with bacteria, fungi and molds as well as endotoxins, mycotoxins and spores associated with these microbes. Several farm operations are known to generate high levels of dust and have been reported to cause adverse physical reactions in farm workers. Symptoms often include fever, headache, malaise and respiratory difficulty. The present report descnbes an animal model which characterizes the pulmonary responses to inhalation of selected agricultural dusts. Bulk samples collected at the farm site can be placed in a container and dust aerosols of respirable size generated by acoustical energy. Guinea pigs can be exposed to these aerosols and their pulmonary responses, such as airway constriction and inflammation, can be monitored as a function of exposure dose and time. This animal model may have the capability to predict the potential biological reactivity of various agricultural materials. In addition, this system could be used to determine the agent( s) associated with agricultural dust which causes disease and to determine the mechanisms by which disease develops.
• Subjects:
  Accidents, Occupational Agriculture Fungi Fungicide, Industrial Insecticides Mutagens Occupational Health Safety Somatotypes
• Keywords:
  Aerosols Agricultural-industry Agricultural-workers Animals Bacteria Biological Effects Confined Spaces Dust Exposure Dusts Environmental Exposure Exposure Levels Families Farmers Farm Workers Grain Dust Hazards Humans Men Models Pulmonary System Disorders Respiratory System Disorders Risk Factors Safety-practices Women Work Environment Worker-health Workers

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• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Abstract ; Abstract
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  563
• NIOSHTIC Number:
  nn:20056000
• Citation:
  Papers and Proceedings of the Surgeon General's Conference on Agricultural Safety and Health (FarmSafe 2000). Myers ML, Herrick RF, Olenchock SA, Myers JR, Parker, John E., Hard DL, Wilson K, eds. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 92-105, 1992 Sep; :563
• Editor(s):
  Myers ML ; Herrick RF ; Olenchock SA ; Myers JR ; Parker, John E. ; Hard DL ; Wilson K ; Myers ML ; Herrick RF ; Olenchock SA ; Myers JR ; Parker, John E. ; Hard DL ; Wilson K
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• Source Full Name:
  Papers and Proceedings of the Surgeon General's Conference on Agricultural Safety and Health (FarmSafe 2000), April 30-May 3, 1991, Des Moines, Iowa
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cbaf4761d5ef30332cba7924f66886ab0a479268f2441264e3963326bd8de2d6fd6d02edfd7992a7d9014f811e683e3d0c953c1ca48fb4b1e3ab0adfa452b2f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/181764/cdc_181764_DS1.pdf
• File Type:
  [PDF - 74.51 KB ]