Oseltamivir Resistance in Adult Oncology and Hematology Patients Infected with Pandemic (H1N1) 2009 Virus, Australia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tramontana, Adrian R. ; George, Biju ; Hurt, Aeron C. ; Doyle, Joseph S. ; Langan, Katherine ; Reid, Alistair B. ; Harper, Janet M. ; Thursky, Karin ; Worth, Leon J. ; Dwyer, Dominic E ; Morrissey, C. Orla ; Johnson, Paul D.R. ; Buising, Kirsty L. ; Harrison, Simon James ; Seymour, John F. ; Ferguson, Patricia E. ; Wang, Bin ; Denholm, Justin T. ; Cheng, Allen C. ; Slavin, Monica
• Description:
  We describe laboratory-confirmed influenza A pandemic (H1N1) 2009 in 17 hospitalized recipients of a hematopoietic stem cell transplant (HSCT) (8 allogeneic) and in 15 patients with malignancy treated at 6 Australian tertiary centers during winter 2009. Ten (31.3%) patients were admitted to intensive care, and 9 of them were HSCT recipients. All recipients of allogeneic HSCT with infection <100 days posttransplantation or severe graft-versus-host disease were admitted to an intensive care unit. In-hospital mortality rate was 21.9% (7/32). The H275Y neuraminidase mutation, which confers oseltamivir resistance developed in 4 of 7 patients with PCR positive for influenza after > or = 4 days of oseltamivir therapy. Three of these 4 patients were critically ill. Oseltamivir resistance in 4 (13.3%) of 30 patients who were administered oseltamivir highlights the need for ongoing surveillance of such resistance and further research on optimal antiviral therapy in the immunocompromised.
• Subjects:
  Antiviral Agents Disease Outbreaks Drug Resistance, Viral Hematopoietic Stem Cell Transplantation Humans Influenza, Human Influenza A Virus, H1N1 Subtype Intensive Care Units Oseltamivir Synopsis Transplantation, Homologous

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• Source:
  Emerg Infect Dis. 16(7):1068-1075.
• Document Type:
  Journal Article
• Place as Subject:
  Australia
• Volume:
  16
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:db10f149c9a507800f7b3304523914a5082f3ccac617fabdf4afbf0b3d94cd82
• Download URL:
  https://stacks.cdc.gov/view/cdc/18151/cdc_18151_DS1.pdf
• File Type:
  [PDF - 165.50 KB ]