The multiple transient dermal dose problem: theory.

Details

• Personal Author:
  Frasch HF ; Frasch HF
• Description:
  Typical workplace dermal exposures can be characterized as multiple transient or intermittent dermal contacts. In this scenario, a given amount of contaminant is in contact with a given area of skin for a given period of time. This cycle is repeated throughout the work day with, in general, different amounts of contaminant in contact with different areas of skin over different time intervals. Here we present solutions for concentration, flux and total mass accumulation for this problem, in which we consider the skin to be a single homogeneous membrane. Analytical solutions are derived in the Laplace domain; numerical methods are required to transform these solutions to the time domain. We show that a simple steady-state solution exists for the total accumulation of contaminant, which is analogous to total systemic uptake. This is the main quantity of interest for dermal risk assessment.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Air Pollution, Indoor Health Care Facilities Workforce And Services Manufacturing And Industrial Facilities Mining Occupational Health Preceptorship Safety Staff Development Surveys And Questionnaires Workplace

  More +
• Keywords:
  Absorption-rates Exposure-assessment In-vitro-studies In-vitro-study Risk-analysis Skin-absorption Skin-disorders Skin-exposure Skin-irritants Skin-tests Statistical-analysis

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• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings ; Conference/Symposia Proceedings
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-6
• NIOSHTIC Number:
  nn:20027241
• Citation:
  Occupational and Environmental Exposures of Skin to Chemicals, June 12-15, 2005, Stockholm, Sweden. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-6
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods ; Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  False
• Source Full Name:
  Occupational and Environmental Exposures of Skin to Chemicals, June 12-15, 2005, Stockholm, Sweden
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:86d9207380904acac12cdde160f1c4ecf2b99bb127538573db23747880410b883837975166ded1105dfe46caa98d9fd5db9ace8c45352fcdc822714950363c81
• Download URL:
  https://stacks.cdc.gov/view/cdc/181310/cdc_181310_DS1.pdf
• File Type:
  [PDF - 701.04 KB ]