Analytical chemistry of metalworking fluids for dermal and inhalation toxicology studies.

Details

• Personal Author:
  Arnold JE ; Brown KK
• Description:
  In support of a National Toxicology Program (NTP) study on metalworking fluids (MWF), NIOSH was provided samples of the fluids being tested in that study [NTP 2004]. Aliquots of these fluids were shared with NIOSH researchers for local lymph node assays (LLNA), skin penetration tests, and chemical analyses. Currently, there is no NIOSH method or literature method for the separation and identification of the major components in a MWF mixture. A method for their analysis is described and preliminary results are reported. The analytical results of this method will provide data to researchers of the NTP, LLNA, and dermal penetration studies and likely impact their conclusions. Liquid and gas phase chromatographic methods were used to characterize the composition of these complex mixtures. The major components in MWFs were separated by high performance liquid chromatography (HPLC) and detected by both ultraviolet (UV) absorption and evaporative light scattering detection (ELSD). The UV detector is a non-destructive specific detector that does not detect all the components, while the ELSD is a destructive "universal detector" capable of detecting most compounds. The ELSD response is a function of analyte mass, and therefore peak areas in a chromatogram reflect the relative abundance of a component in the MWF. The ELSD was used to locate the major components in a MWF with respect to UV-ELSD active internal standards.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Air Pollution, Indoor Aldehydes Formaldehyde Health Care Facilities Workforce And Services Manufacturing And Industrial Facilities Occupational Health Preceptorship Safety Staff Development Surveys And Questionnaires Textile Industry Workplace

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• Keywords:
  Absorption-rates Chromatographic-analysis Metal-workers Metallic-compounds Metallic-fumes Metallic-poisoning Metallic-poisons Metalworking Metalworking-fluids Metalworking-industry Skin-absorption Skin-cancer Skin-diseases Skin-disorders Skin-exposure Skin-irritants Skin-tests Statistical-analysis

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• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Abstract
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-2
• NIOSHTIC Number:
  nn:20027227
• Citation:
  Occupational and Environmental Exposures of Skin to Chemicals, June 12-15, 2005, Stockholm, Sweden. Morgantown, WV: National Institute for Occupational Safety and Health, 2005 Jun; :1-2
• CAS Registry Number:
  Triethanolamine (CAS RN 102-71-6) ; 4-Chloro-3-methylphenol (CAS RN 59-50-7) ; Palmitic acid (CAS RN 57-10-3)
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  False
• Source Full Name:
  Occupational and Environmental Exposures of Skin to Chemicals, June 12-15, 2005, Stockholm, Sweden
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:84fc3cdbcc3428425b102eb17575d93d0b1641120aaa7daf1abe26328d2ad643b4fd5b0299c91fc9c5e91a8ed50635be25d3d306e2bd0b262d903f52c96774f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/181304/cdc_181304_DS1.pdf
• File Type:
  [PDF - 510.59 KB ]