Ebola Hemorrhagic Fever Associated with Novel Virus Strain, Uganda, 2007–2008

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Wamala, Joseph F. ; Lukwago, Luswa ; Malimbo, Mugagga ; Nguku, Patrick ; Yoti, Zabulon ; Musenero, Monica ; Amone, Jackson ; Mbabazi, William ; Nanyunja, Miriam ; Zaramba, Sam ; Opio, Alex ; Lutwama, Julius J. ; Talisuna, Ambrose O. ; Okware, Sam I.
• Description:
  During August 2007-February 2008, the novel Bundibugyo ebolavirus species was identified during an outbreak of Ebola viral hemorrhagic fever in Bundibugyo district, western Uganda. To characterize the outbreak as a requisite for determining response, we instituted a case-series investigation. We identified 192 suspected cases, of which 42 (22%) were laboratory positive for the novel species; 74 (38%) were probable, and 77 (40%) were negative. Laboratory confirmation lagged behind outbreak verification by 3 months. Bundibugyo ebolavirus was less fatal (case-fatality rate 34%) than Ebola viruses that had caused previous outbreaks in the region, and most transmission was associated with handling of dead persons without appropriate protection (adjusted odds ratio 3.83, 95% confidence interval 1.78-8.23). Our study highlights the need for maintaining a high index of suspicion for viral hemorrhagic fevers among healthcare workers, building local capacity for laboratory confirmation of viral hemorrhagic fevers, and institutionalizing standard precautions.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool Disease Outbreaks Ebolavirus Female Hemorrhagic Fever, Ebola Humans Infant Infant, Newborn Male Middle Aged Risk Factors Time Factors

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• Source:
  Emerg Infect Dis. 16(7):1087-1092.
• Document Type:
  Journal Article
• Place as Subject:
  Uganda
• Volume:
  16
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:463633e530d63e48b0f964393615a432a4bb7542178312dec3b679ae587cc086
• Download URL:
  https://stacks.cdc.gov/view/cdc/18114/cdc_18114_DS1.pdf
• File Type:
  [PDF - 146.36 KB ]