Livestock-associated Methicillin-Resistant Staphylococcus aureus Sequence Type 398 in Humans, Canada

Golding, George R.; Bryden, Louis; Levett, Paul N.; McDonald, Ryan R.; Wong, Alice; Wylie, John; Graham, Morag R.; Tyler, Shaun; Van Domselaar, Gary; Simor, Andrew E.; Gravel, Denise; Mulvey, Michael R.

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Livestock-associated Methicillin-Resistant Staphylococcus aureus Sequence Type 398 in Humans, Canada

Supporting Files Public Domain

Apr 2010
By Golding, George R. ; Bryden, Louis ; Levett, Paul N. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Golding, George R. ; Bryden, Louis ; Levett, Paul N. ; McDonald, Ryan R. ; Wong, Alice ; Wylie, John ; Graham, Morag R. ; Tyler, Shaun ; Van Domselaar, Gary ; Simor, Andrew E. ; Gravel, Denise ; Mulvey, Michael R.
Description:

Rates of colonization with livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) sequence type 398 have been high for pigs and pig farmers in Canada, but prevalence rates for the general human population are unknown. In this study, 5 LA-MRSA isolates, 4 of which were obtained from skin and soft tissue infections, were identified from 3,687 tested MRSA isolates from persons in Manitoba and Saskatchewan, Canada. Further molecular characterization determined that these isolates all contained staphylococcal cassette chromosome (SCC) mecV, were negative for Panton-Valentine leukocidin, and were closely related by macrorestriction analysis with the restriction enzyme Cfr91. The complete DNA sequence of the SCCmec region from the isolate showed a novel subtype of SCCmecV harboring clustered regularly interspaced short palindromic repeats and associated genes. Although prevalence of livestock-associated MRSA seems to be low for the general population in Canada, recent emergence of infections resulting from this strain is of public health concern.
Subjects:

Aged Animals Animals, Domestic Bacterial Toxins Deoxyribonucleases, Type Ii Site-Specific Exotoxins Female Genes, Bacterial Humans Inverted Repeat Sequences Leukocidins Male Manitoba Middle Aged Mutagenesis, Insertional Prevalence Staphylococcal Infections Swine
Source:

Emerg Infect Dis. 16(4):587-594.
Document Type:

Journal Article
Place as Subject:

Saskatchewan, Canada
Location:

North America
Volume:

16
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:bf7e7d621328c587288daeef933f02cc2831b1d21360dc0ca77f4e5362015224
Download URL:

https://stacks.cdc.gov/view/cdc/18101/cdc_18101_DS1.pdf
File Type:

[PDF - 387.36 KB ]

File Language:

English

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