Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Golding, George R. ; Bryden, Louis ; Levett, Paul N. ; McDonald, Ryan R. ; Wong, Alice ; ... More +
Golding, George R. ; Bryden, Louis ; Levett, Paul N. ; McDonald, Ryan R. ; Wong, Alice ; Wylie, John ; Graham, Morag R. ; Tyler, Shaun ; Van Domselaar, Gary ; Simor, Andrew E. ; Gravel, Denise ; Mulvey, Michael R. ; Less -
Description:
Rates of colonization with livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) sequence type 398 have been high for pigs and pig farmers in Canada, but prevalence rates for the general human population are unknown. In this study, 5 LA-MRSA isolates, 4 of which were obtained from skin and soft tissue infections, were identified from 3,687 tested MRSA isolates from persons in Manitoba and Saskatchewan, Canada. Further molecular characterization determined that these isolates all contained staphylococcal cassette chromosome (SCC) mecV, were negative for Panton-Valentine leukocidin, and were closely related by macrorestriction analysis with the restriction enzyme Cfr91. The complete DNA sequence of the SCCmec region from the isolate showed a novel subtype of SCCmecV harboring clustered regularly interspaced short palindromic repeats and associated genes. Although prevalence of livestock-associated MRSA seems to be low for the general population in Canada, recent emergence of infections resulting from this strain is of public health concern.
Subject:
[+]
Aged
Animals
Animals, Domestic
Bacteria
Bacterial Toxins
Canada
CRISPR
Deoxyribonucleases, Type II Site-Specific
Exotoxins
Expedited
Female
Genes, Bacterial
Humans
Inverted Repeat Sequences
Leukocidins
Livestock Associated
Male
Manitoba
Methicillin-resistant Staphylococcus Aureus
Middle Aged
Mutagenesis, Insertional
Prevalence
Research
Saskatchewan
SCCmec
ST398
Staphylococcal Infections
Swine
Zoonoses
Methicillin-Resistant Staphylococcus Aureus

Source:
Emerg Infect Dis. 16(4):587-594.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:bf7e7d621328c587288daeef933f02cc2831b1d21360dc0ca77f4e5362015224
File Type:

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