Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Influenza A (H7N7) Epidemic, the Netherlands, 2003

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  te Beest, Dennis E. ; van Boven, Michiel ; Bos, Marian E.H. ; Stegeman, Arjan ; Koopmans, Marion P.G.
• Description:
  We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95% confidence interval CI 0.078-0.233) to 0.031 (95% CI 0.008-0.073). The protective effect was ≈79% (95% CI 40%-97%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.
• Subjects:
  • Research
  • Adolescent
  • Adult
  • Animal Husbandry
  • Animals
  • Antiviral Agents
  • Chemoprevention
  • Disease Outbreaks
  • Eye Protective Devices
  • Female
  More +
• Source:
  Emerg Infect Dis. 16(10):1562-1568.
• Document Type:
  Journal Article
• Funding:
  1U19CI000404-02/CI/NCPDCID CDC HHS/United States
• Place as Subject:
  Netherlands
• Location:
  Europe
• Volume:
  16
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/18097/cdc_18097_DS1.pdf
• File Type:
  [PDF - 214.56 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:efe5e9fa93eb9591c987f59a52239ed82faa237efeae0f6eaade038e6a638008