Effectiveness of Personal Protective Equipment and Oseltamivir Prophylaxis during Avian Influenza A (H7N7) Epidemic, the Netherlands, 2003

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  te Beest, Dennis E. ; van Boven, Michiel ; Bos, Marian E.H. ; Stegeman, Arjan ; Koopmans, Marion P.G.
• Description:
  We analyzed the effectiveness of personal protective equipment and oseltamivir use during the 2003 avian influenza A (H7N7) epidemic in the Netherlands by linking databases containing information about farm visits, human infections, and use of oseltamivir and personal protective equipment. Using a stringent case definition, based on self-reported conjunctivitis combined with a positive hemagglutination-inhibition assay, we found that prophylactic treatment with oseltamivir significantly reduced the risk for infection per farm visit from 0.145 (95% confidence interval [CI] 0.078-0.233) to 0.031 (95% CI 0.008-0.073). The protective effect was ≈79% (95% CI 40%-97%). These results are comparable with the reported effect of prophylactic treatment with oseltamivir on human seasonal influenza. No significant protective effect was found for use of respirators or safety glasses, possibly because of limitations of the data.
• Subjects:
  Adolescent Adult Animal Husbandry Animals Antiviral Agents Chemoprevention Disease Outbreaks Eye Protective Devices Female Humans Influenza, Human Influenza A Virus, H7N7 Subtype Influenza In Birds Male Middle Aged Occupational Exposure Oseltamivir Poultry Poultry Diseases Protective Devices Research Respiratory Protective Devices Treatment Outcome Young Adult

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• Source:
  Emerg Infect Dis. 16(10):1562-1568.
• Document Type:
  Journal Article
• Funding:
  1U19CI000404-02/CI/NCPDCID CDC HHS/United States
• Place as Subject:
  Netherlands
• Location:
  Europe
• Volume:
  16
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:efe5e9fa93eb9591c987f59a52239ed82faa237efeae0f6eaade038e6a638008
• Download URL:
  https://stacks.cdc.gov/view/cdc/18097/cdc_18097_DS1.pdf
• File Type:
  [PDF - 214.56 KB ]