Study on suppression of soluble aluminum aerosols on quartz-induced cytotoxicity - combined effects of both aerosols in an artificial dust atmosphere.

Details

• Personal Author:
  Jin C ; Liu S
• Description:
  The cytotoxicity of aluminum (7429905) coated crystalline silica (14808607) (quartz) aerosols was evaluated in-vitro. Aerosols of soluble aluminum compounds (AlAs) and quartz were generated by an ultrasonic nebulizer. The amounts of aluminum adsorbed on the quartz particles and the particle size distributions of the aerosols were determined. Quartz aerosols containing 0 to 1.0 milligram per milliliter aluminum were generated and incubated with guinea-pig alveolar macrophages and rat erythrocytes. Cytotoxicity was assessed by measuring the extent of erythrocyte hemolysis and macrophage viability. The amounts of aluminum adsorbed on the quartz particles ranged from 0.09 to 0.15 micrograms per square centimeter. Coverage of the quartz surface by aluminum increased with decreasing particle size. The amount of aluminum adsorbed on a quartz particle with diameter 2.54 microns (micron) was nine times that of a particle having diameter 1.97micron. The aluminum coated particles were significantly less cytotoxic than the uncoated particles. The decrease in cytotoxicity generally increased with increasing concentration of adsorbed aluminum. The authors conclude that AlAs can combine with quartz particles to form stable dusts of aluminum coated particles. The aluminum coated particles are significantly less cytotoxic to macrophages and erythrocytes than uncoated particles.
• Subjects:
  Accidents, Occupational Environmental Monitoring Hazardous Substances Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Safety
• Keywords:
  Alveolar Cells Cytotoxic Effects Dust Exposure In Vitro Studies Red Blood Cells Silica Dusts Surface Properties
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1299-1303
• NIOSHTIC Number:
  nn:00198790
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Pt II):1299-1303
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:59e89ff33e92032a1ae4f809fa9642b8470f75eebcef4432113ee2369bbeb1144c153d565d7932323b11edee23601a9d7129074cbe7bff6e126a32f20f8092fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/180665/cdc_180665_DS1.pdf
• File Type:
  [PDF - 182.97 KB ]