An attempt for evaluation of the alveolar dust deposition on the base of the particle size distributions of lung dusts.

Details

• Personal Author:
  Ivanova-Djoubrilova S ; Tcherneva P
• Description:
  The particle size distributions of mine dusts and dusts recovered from the lungs of workers employed in underground mines (lung dusts) were determined. Mass particle size distributions of 24 dust samples obtained from a polymetal ore mine and 23 samples obtained from two copper mines were determined using the Joyce-Loebl disc centrifuge (Joyce method) and Coulter Counter (CC) techniques. The mass particle size distributions of dusts recovered at autopsy from the lungs of 43 miners who had been employed at the polymetal mine and 16 who had worked at the two copper mines were also determined. The amounts of the dusts deposited and retained in the alveoli (alveolar retention) were determined from the data. The mass median aerodynamic diameters (MMADs) of the three mine dusts were in the range 3 to 5 microns when analyzed by either technique. The mean geometric standard deviations of the MMADs were 4.4 to 5.3 microns for the Joyce analysis and 2.2 to 2.3 microns for the CC analysis. The mean MMADs of the particle size distributions of the lung dusts ranged from 1.9 to 2.6 microns. The mean geometric standard deviations ranged from 3.3 to 3.6 and from 1.6 to 1.8 when analyzed by the Joyce and CC techniques, respectively. Maximum alveolar retention of the dusts occurred for particles having diameters of 1.2 to 4.2 microns. The maximum alveolar retention predicted by theoretical curves of Yu and the International Commission on Radiological Protection occurred for 1.6 to 3.2 and 3.2 to 6.5 microns size particles, respectively. The authors conclude that alveolar retention of inhaled dusts determined from particle size distributions of lung dust is different from that of monodispersed aerosols. The polydispersity of dusts has a significant influence on their alveolar retention.
• Subjects:
  Accidents, Occupational Bromine Compounds Hydrocarbons Insecticides Manufacturing And Industrial Facilities Occupational Health Personal Protective Equipment Protective Clothing Safety
• Keywords:
  Dust Analysis Industrial Hygiene Lung Burden Mathematical Models Mine Workers Occupational Exposure Respirable Dust Statistical Analysis
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  933-937
• NIOSHTIC Number:
  nn:00198683
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):933-937
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b6d459c1876bd15e4a2b6c3708cfcdd0d88657eede66df40a628a03392e8f0ff04ca15bf6ab3c78bf4c03e0681d5f6de9094cee806a0bc1e56ece00189667bef
• Download URL:
  https://stacks.cdc.gov/view/cdc/180598/cdc_180598_DS1.pdf
• File Type:
  [PDF - 161.31 KB ]