Newer concepts in silica and silicate lung disease.

Details

• Personal Author:
  Gibbs AR ; Gibbs AR
• Description:
  Results obtained through a series of autopsy lung studies from a group of Cornish china clay workers were presented. The industry began in the eighteenth century when china clay and china stone deposits were worked and the products used in British pottery production. There was good agreement obtained between the occupational histories and the mineral content of the lungs. Nodular fibrosis correlated better with quartz (14808607) concentrations than kaolinite (1318747). Interstitial fibrosis correlated better with kaolinite concentration than nodular fibrosis. In the majority of cases it was relatively easy to separate the china clay cases from the china clay and china stone cases histologically. The author concludes that a pneumoconiosis may result from nonfibrous silicates in the absence of free silica (7631869), in this case kaolin (1332587), and interstitial fibrosis is the predominant lesion. Further studies of this type are needed to understand the toxic effects of free silica and nonfibrous silicates on the human lung.
• Subjects:
  Accidents, Occupational Computers Occupational Health Safety Urogenital Diseases
• Keywords:
  Airborne Dusts Body Burden Coal Dust Dust Inhalation Lung Burden Mineral Dusts Occupational Exposure Silica Dusts Tissue Distribution
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings ; Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1160-1161
• NIOSHTIC Number:
  nn:00198591
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1160-1161
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7) ; Kaolinite (Al2(OH)4(Si2O5)) (CAS RN 1318-74-7) ; Silica (CAS RN 7631-86-9) ; Kaolin (CAS RN 1332-58-7) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Kaolinite (Al2(OH)4(Si2O5)) (CAS RN 1318-74-7) ; Silica (CAS RN 7631-86-9) ; Kaolin (CAS RN 1332-58-7)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0e2b4550ba493221be3e3773718dcdf202b8595b48c0cc00a9ed60c4c8fc32b0cae917d002c38d46978a74e10f14b27be4e75f4a9022187bd2c05cbcf2c62d00
• Download URL:
  https://stacks.cdc.gov/view/cdc/180554/cdc_180554_DS1.pdf
• File Type:
  [PDF - 87.41 KB ]