Element analyses in human lung tissue correlated with smoking, emphysema and lung cancer.

Details

• Personal Author:
  Anttila S ; Kalliomaki K ; Kalliomaki PL ; Kokkonen P ; Paakko P
• Description:
  An investigation was conducted to determine the concentrations of light elements derived mainly from minerals, heavy metals and essential trace elements in human lung tissue. The elemental concentrations observed in lung tissue were related to smoking, emphysema, and lung cancer. The lung specimens were collected from subjects without any malignant disease and from lung cancer patients. The concentrations of magnesium (7439954), titanium (7440326), chromium (7440473), and cadmium (7440439) were higher in the surgical specimens of lung cancer patients than in autopsy lung tissue of nonmalignant subjects. The severity of emphysema was related to the increase of the concentrations of calcium (7440702), cadmium and chromium. The moderate and severe emphysema was related to the decrease of the concentration of copper (7440508) and iron (7439896). In lung tissue of nonmalignant autopsy lungs the effect of severity of emphysema was more prominent. A positive correlation, but not statistically significant, was noted between the concentrations of chromium and cadmium and smoking time in the nonmalignant autopsy lungs of the current smokers. The surgical specimens revealed no significant trend in the concentration of any element as a function of smoking time. The concentration of cadmium was significantly decreased in lung tissue of exsmokers in both groups. A relative correlation was noted between nonsmoking years and the cadmium lung content among exsmokers. The concentration of chromium was slightly higher in the lung tissue of exsmokers than in that of current smokers.
• Subjects:
  Accidents, Occupational Coal Coal Mining Mining Occupational Health Safety
• Keywords:
  Body Burden Chemical Analysis Cigarette Smoking Dust Inhalation Lung Burden Mineral Dusts Respiratory System Disorders Tissue Distribution
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1083-1086
• NIOSHTIC Number:
  nn:00198578
• Citation:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1083-1086
• CAS Registry Number:
  Magnesium (CAS RN 7439-95-4) ; Titanium (CAS RN 7440-32-6) ; Chromium (CAS RN 7440-47-3) ; Cadmium (CAS RN 7440-43-9) ; Calcium (CAS RN 7440-70-2) ; Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Part Number:
  II
• Source Full Name:
  Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1e95e92cc0d8e15590b17c377c42caa921494f84383ca2857d05f6145d5bae8f6f67233bae5b1b5aa66dc87431cc90a1c30cf31e7ebb0d8e9b3c47b1655c0b61
• Download URL:
  https://stacks.cdc.gov/view/cdc/180542/cdc_180542_DS1.pdf
• File Type:
  [PDF - 118.79 KB ]