Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Rodenburg, Gerwin D. ; de Greeff, Sabine C. ; Jansen, Angelique G.C.S. ; de Melker, Hester E. ; Schouls, Leo M. ; ... More +
Rodenburg, Gerwin D. ; de Greeff, Sabine C. ; Jansen, Angelique G.C.S. ; de Melker, Hester E. ; Schouls, Leo M. ; Hak, Eelko ; Spanjaard, Lodewijk ; Sanders, Elisabeth A.M. ; van der Ende, Arie Less -
Description:
In the Netherlands, the 7-valent pneumococcal conjugate vaccine (PCV-7) was implemented in a 3+1-dose schedule in the national immunization program for infants born after April 1, 2006. To assess the vaccine's effectiveness, we compared disease incidence before and after vaccine implementation (June 2004-June 2006 and June 2006-June 2008, respectively). We serotyped 2,552 invasive pneumococcal isolates from throughout the Netherlands, covering 25% of the country's population. Clinical characteristics were extracted from hospital records. After June 2006, vaccine-serotype invasive pneumococcal disease (IPD) decreased 90% (95% confidence interval [CI] 68%-97%) in children age eligible for PCV-7; simultaneously, however, non-vaccine-serotype IPD increased by 71% (not significant), resulting in a 44% total net IPD reduction (95% CI 7%-66%). IPD rates did not change for other age groups. In the Netherlands, PCV-7 offered high protection against vaccine-serotype IPD in vaccinated children, but increases of non-vaccine-serotype IPD reduced net vaccine benefits.
Subject:
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Adolescent
Adult
Aged
Age Factors
Bacteria
Child
Child, Preschool
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Incidence
Infant
Middle Aged
Netherlands
Pneumococcal Infections
Pneumococcal Vaccines
Population Surveillance
Research
Serotyping
Streptococcus Pneumoniae
Surveillance
Time Factors
Treatment Outcome
Pneumococcal Infections

Source:
Emerg Infect Dis. 16(5):816-823.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:2db1a2d22003fbad0ef902954b720c01df110fd05d08b2e731f131decda336a8
File Type:

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