Screening of priority chemicals for reproductive hazards. Benzyl alcohol (CAS No. 100-51-6), probenecid (CAS No. 57-66-9), trans-retinoic acid (CAS No. 302-79-4).

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Selected chemicals were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. In the first two phases of the study attempts were made to determine the median lethal dose to be used and in the third phase, reproductive effects were monitored. Treatments were administered by gavage on 5 consecutive days in phase one and on gestation days 6 through 15 in phases two and three. Probenecid (57669) at 1300mg/kg/day was toxic to some maternal animals. Benzyl-alcohol (100516) and all trans- retinoic-acid (302794) doses produced no treatment related deaths in maternal animals. Benzyl-alcohol and probenecid caused no significant changes in maternal weight. The predicted median lethal dose for benzyl-alcohol was 550mg/kg/day and that for probenecid was 1300mg/kg/day. Neither chemical had a significant effect on the gestation index, reproductive index, maternal status, litter size or postnatal survival, average litter weight or weight gain among the pups. Neither chemical produced any evidence of developmental toxicity despite the maternal mortality caused by probenecid.
• Subjects:
  Accidents, Occupational Chemistry Manufacturing And Industrial Facilities Occupational Health Safety Toxicology Workplace
• Keywords:
  Carcinogens Contract-200-84-2735 Embryotoxicity Fetus Laboratory-animals NIOSH-Contract Reproductive-effects Solvents Teratogenesis Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-59
• NIOSHTIC Number:
  nn:00183526
• Citation:
  NIOSH 1986 Sep; :1-59
• CAS Registry Number:
  Probenecid (CAS RN 57-66-9) ; Benzyl alcohol (CAS RN 100-51-6) ; Retinoic acid (CAS RN 302-79-4)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  False
• Source Full Name:
  Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:953dde38f6630e2c6d7e062dcf077f7d2968a3b78fa7baee58e37545c378a961638f51cf30819d4de3a9c42c092514600dfdf8f127275d59d99e7c203ba769bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/180118/cdc_180118_DS1.pdf
• File Type:
  [PDF - 632.94 KB ]