Mutagenicity of 13 NIOSH priority compounds.

Details

• Personal Author:
  McGregor DB ; Niemeier RW ; Schuler RL
• Description:
  The mutagenicities of 3-chloropropene (107051) (CPP), cyclohexanone (108941), methyl-bromide (74839), N,N-dimethylacetamide (127195) (DMAA), N-N-dimethylformamide (68122) (DMFA), N- methyldicyclohexylamine (7560830) (MDCHA), 2-nitropropane (79469), butylene-oxide (26249207), bis(2-methoxyethyl)ether (111966) (BMEE), hexachloro-1,3-butadiene (87683) (HCB), 2-methoxyethanol (109864) (MOE), styrene-oxide (96093), and 1,1,2,2-tetrachloroethane (79345) (TCE) were studied. Dominant lethal, sperm morphology, and bone marrow cytology assays were performed after inhalation exposure of rats and mice 7 hours per day for 5 days. Unscheduled DNA synthesis was measured in-vitro in human embryonic intestinal cells treated for 3 hours at eight concentrations that ranged as high as 9,900 micrograms per milliliter (microg/ml) and as low as 50microg/ml. Drosophila recessive lethal testing exposed flies to various concentrations of the 13 compounds for varying amounts of time. CPP, cyclohexanone, methyl-bromide, DMAA, DMFA, MDCHA, and 2- nitropropane induced no genetic damage. BMEE and MOE produced a strong antifertility effect and some genetic toxicity, and styrene- oxide produced a similar effect but no genetic toxicity. Butylene- oxide produced negative results except in the bone marrow cytology assay where results were questionable. HCB also produced a questionable bone marrow cytology result and exerted an unclear influence during the dominant lethal assay. TCE produced borderline results during both the bone marrow cytology and sperm morphology assays.
• Subjects:
  Accidents, Occupational Animals Coloring Agents Energy Metabolism Hazardous Substances Neoplasms Occupational Diseases Occupational Health Safety
• Keywords:
  Analytical-instruments Biological-effects Carcinomas Chemical-analysis Exposure-levels NIOSH-Author Quantitative-analysis Toxicology Tumorigens
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Other
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-31
• NIOSHTIC Number:
  nn:00155937
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1982 Jan; :1-31
• CAS Registry Number:
  Allyl chloride (CAS RN 107-05-1) ; Cyclohexanone (CAS RN 108-94-1) ; Methyl bromide (CAS RN 74-83-9) ; Dimethylacetamide (CAS RN 127-19-5) ; Dimethylformamide (CAS RN 68-12-2) ; Methyldicyclohexylamine (CAS RN 7560-83-0) ; 2-Nitropropane (CAS RN 79-46-9) ; Butylene oxide (CAS RN 26249-20-7) ; Diglyme (CAS RN 111-96-6) ; Hexachlorobutadiene (CAS RN 87-68-3) ; 2-Methoxyethanol (CAS RN 109-86-4) ; Styrene oxide (CAS RN 96-09-3) ; 1,1,2,2-Tetrachloroethane (CAS RN 79-34-5)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fe844800427d462775ac08ecf2e827edc3ecf3fb343420a157f19edd69178aec49a176c6599d56330c55faf41b00eec31dcc68b0ae5d077baeed216b7f9fdd59
• Download URL:
  https://stacks.cdc.gov/view/cdc/179777/cdc_179777_DS1.pdf
• File Type:
  [PDF - 356.66 KB ]