Carcinogenic potential of condensed pyrolysis effluents from iron foundry casting operations, volume V.

Details

• Personal Author:
  Garner FM ; Plankenhorn LJ ; Shellenberger TE
• Description:
  Data tabulations for a carcinogenesis bioassay of condensed effluents from iron foundry casting operations that used hamsters as the test species are presented. In that study, Syrian-golden- hamsters were administered effluents from shell sand, green sand, furan (110009), or urethane (51796) casting molds once a week for 18 weeks by intratracheal instillation. The concentrations were 5 or 10 milligrams (mg) effluent in 0.2 milliliter of distilled water, except for the effluents from the urethane mold, which were administered in amounts of 2.5 or 5.0mg. Benzo(a)pyrene (50328) plus ferric-oxide (1309371) and ferric-oxide alone were administered as positive controls. The animals were maintained until 98 percent mortality occurred or until week 103 in the case of females or week 117 in the case of males. None of the effluents were found to be carcinogenic at the concentrations used. The histopathological results for each individual animals were tabulated. A tumor inventory for each animal was also constructed.
• Subjects:
  Accidents, Occupational Manufacturing And Industrial Facilities Nitriles Occupational Health Preceptorship Safety
• Keywords:
  Contract-210-78-0033 Equipment-design Iron-oxide-fumes Iron-working-industry Lung-fibrosis NIOSH-Contract Pharmacodynamics Pyrolysis Quantitative-analysis Toxicology
• Document Type:
  Text
• Funding:
  Contract
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-211
• NIOSHTIC Number:
  nn:00144931
• Citation:
  NIOSH 1984 Oct; :1-211
• CAS Registry Number:
  Furan (CAS RN 110-00-9) ; Carbamic acid, ethyl ester (CAS RN 51-79-6) ; Benzo[a]pyrene (CAS RN 50-32-8) ; Iron oxide (Fe2O3) (CAS RN 1309-37-1)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  False
• Source Full Name:
  Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1dc010789ec342c44c3d900b17d41f6f8a7b222e6b073aafefc5022915a37820052a51c5a9d62b01f3383e76ff737633b101dae6ddd2ac14f1d2ff76e8fd4caa
• Download URL:
  https://stacks.cdc.gov/view/cdc/179697/cdc_179697_DS1.pdf
• File Type:
  [PDF - 7.83 MB ]