Hazard review of 2-acetylaminofluorene (2-AAF).

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The toxic hazards of exposure to 2-acetylaminofluorene (53963) (2- AAF) are discussed. Dietary dose response studies in rats are described in which induction times were determined for tumor development, especially liver and kidney tumors. Other studies are summarized on the incidence of eye, mammary, ear duct, and liver tumors in rats fed 2-AAF, and on the effects of other dietary components on 2-AAF carcinogenicity including casein (9000719), tryptophane (73223), indole (120729), vitamin-B6 (8059243), and liver powder. Cellular and biochemical changes caused by 2-AAF are described, such as development of nodular and non nodular foci in the liver; increases in glycogen, glucuronyl-transferase, glutathione-reductase, and uridinediphosphoglucose; and decreases in liver catalase, alkaline RNase, and serum alkaline RNase. The effect of hormones on 2-AAF carcinogenicity is discussed, and research findings are reviewed on 2-AAF carcinogenic antagonists, metabolic fate, and species differences in carcinogenic response. The author concludes that 2-AAF has been proven to be carcinogenic in rats, mice, rabbits, dogs, hamsters, and fowl, and should probably be considered as a human carcinogen.
• Subjects:
  Accidents, Occupational Dioxins Environmental Pollution Hydrocarbons Manufacturing And Industrial Facilities Occupational Health Safety
• Keywords:
  Animal-studies Biological-effects Comparative-toxicology Hepatotoxicity Medical-research NIOSH-Author Pesticides Renal-toxicity Toxicology Tumorigens
• Document Type:
  Text
• Genre:
  Other
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ORSD - Office of Research and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-14
• NIOSHTIC Number:
  nn:00136149
• Citation:
  NIOSH 1973 Jul; :1-14
• CAS Registry Number:
  AAF (CAS RN 53-96-3) ; Caseins (CAS RN 9000-71-9) ; L-Tryptophan (CAS RN 73-22-3) ; Indole (CAS RN 120-72-9) ; Vitamin B6 (CAS RN 8059-24-3)
• Federal Fiscal Year:
  1973
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8c27e736306ec757c7a7897b2fb7bbcdb3dcff5a2272b467e494f4a0d0ff96a8179b739f40732143dd8d517b498f904ff5e6aa185cd93d87bc8677c405ec1968
• Download URL:
  https://stacks.cdc.gov/view/cdc/179677/cdc_179677_DS1.pdf
• File Type:
  [PDF - 690.91 KB ]